2. Stem Cell/Wnt
  3. Porcupine Wnt β-catenin
  4. WHN-88

WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice.

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WHN-88 Chemical Structure

WHN-88 Chemical Structure

CAS No. : 2490686-86-5

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Description

WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice[1].
Molecular Weight

557.12

Formula

C18H13I2N3O2
CAS No.
SMILES

O=C(CN1C=C(I)C(C(I)=C1)=O)NC2=NC=C(C3=CC=CC=C3)C=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WHN-88 Related Classifications

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Keywords:

WHN-882490686-86-5WHN88WHN 88PorcupineWntβ-cateninBeta cateninPORCNWnt/β-cateninpalmitoylationbreast tumorInhibitorinhibitorinhibit

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