SAG

By Targets:	DAGL (1) HBV (1) HCN Channel (1) Hedgehog (1) Small Interfering RNA (siRNA) (1) Smo (7)
By Research Areas:	Cancer (6) Infection (1) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12848

*SAG* Maximum Cited Publications 23 Publications Verification	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848R

SAG (Standard)	Smo	Cancer
SAG (Standard) is the analytical standard of SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848S

SAG-d3	Smo	Cancer
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

HY-12848B

SAG hydrochloride Maximum Cited Publications 23 Publications Verification	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848C

SAG dihydrochloride Maximum Cited Publications 23 Publications Verification	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-124899

Hh-Ag1.5 1 Publications Verification SAG1.5	Hedgehog	Metabolic Disease
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC₅₀ of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .

HY-110240

IHR-1	Smo	Others
IHR-1 is a cell membrane impermeable Smo antagonist .

HY-157993

SAG-524	HBV	Infection
SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC₅₀ 0.92 and 1.4 nM, respectively .

HY-RS12415

SAG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SAG Human Pre-designed siRNA Set A contains three designed siRNAs for SAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SAG Human Pre-designed siRNA Set A SAG Human Pre-designed siRNA Set A

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-117771

DO34 2 Publications Verification	DAGL	Metabolic Disease
DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC₅₀ for DAGLβ.

HY-163455

pan-HCN-IN-1	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

Cat. No.	Product Name	Target	Research Area

HY-134017

Acetyl dipeptide-1 cetyl ester Calmosensine	Peptides	Others
Acetyl dipeptide-1 cetyl ester (Calmosensine) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Species:	Human (5)
Tag:	His (4) GST (2)
Source:	HEK293 (1) P. pastoris (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71781

	SAG Protein, Human (P.pastoris, His) 48kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; S antigen; S arrestin; S-AG; S-arrestin; SAG	Human	P. pastoris
	SAG proteins play a crucial role in phototransduction, regulating signal transduction by binding to light-activated and phosphorylated rhodopsin (RHO). It terminates RHO signaling by competitively interacting with G proteins at the same binding site on RHO. SAG Protein, Human (P.pastoris, His) is the recombinant human-derived SAG protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of SAG Protein, Human (P.pastoris, His) is 405 a.a., with molecular weight of ~47.1 kDa.

HY-P75710

	DMBT1 Protein, Human (HEK293, His) Deleted in malignant brain tumors 1 protein; Glycoprotein 340; Gp-340; Hensin; SAG; DMBT1	Human	HEK293
	The DMBT1 protein is a potential tumor suppressor in a variety of cancers and affects a variety of biological processes. It contributes to mucosal and cellular immune defense, epithelial differentiation, and serves as an opsonin receptor for SFTPD and SPAR in macrophages. DMBT1 Protein, Human (HEK293, His) is the recombinant human-derived DMBT1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DMBT1 Protein, Human (HEK293, His) is 201 a.a., with molecular weight of 35-45 kDa.

HY-P79168

	Hyaluronan Lyase Protein, S. agActiae (His) Hyaluronidase; SAG1197	Others	E. coli
	Hyaluronan Lyase Protein, S. agActiae (His) is the recombinant Hyaluronan Lyase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Hyaluronan Lyase Protein, S. agActiae (His) is 814 a.a., with molecular weight of ~85 kDa.

HY-P702792

	CRIP1 Protein, Human (GST) CKBBP1; CKII beta binding protein 1; CKII beta-binding protein 1; Rbx 2; Rbx2; RBX2_HUMAN; Regulator of cullins 2; RING box protein 2; RING finger protein 7; RING-box protein 2; RNF 7; RNF7; ROC 2; ROC2; SAG; Sensitive to apoptosis gene; Sensitive to apoptosis gene protein; Zinc RING finger protein SAG	Human	E. coli
	CRIP1 Protein, Human (GST) is the recombinant human-derived CRIP1, expressed by E. coli , with N-GST labeled tag. The total length of CRIP1 Protein, Human (GST) is 77 a.a.,

HY-P702790

	RNF7 Protein, Human (P.pastoris, His) CKBBP1; CKII beta binding protein 1; CKII beta-binding protein 1; Rbx 2; Rbx2; RBX2_HUMAN; Regulator of cullins 2; RING box protein 2; RING finger protein 7; RING-box protein 2; RNF 7; RNF7; ROC 2; ROC2; SAG; Sensitive to apoptosis gene; Sensitive to apoptosis gene protein; Zinc RING finger protein SAG	Human	P. pastoris
	RNF7 Protein, Human (P.pastoris, His) is the recombinant human-derived RNF7, expressed by P. pastoris , with N-6*His labeled tag. ,

HY-P702791

	RNF7 Protein, Human (GST) CKBBP1; CKII beta binding protein 1; CKII beta-binding protein 1; Rbx 2; Rbx2; RBX2_HUMAN; Regulator of cullins 2; RING box protein 2; RING finger protein 7; RING-box protein 2; RNF 7; RNF7; ROC 2; ROC2; SAG; Sensitive to apoptosis gene; Sensitive to apoptosis gene protein; Zinc RING finger protein SAG	Human	E. coli
	RNF7 Protein, Human (GST) is the recombinant human-derived RNF7, expressed by E. coli , with N-GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-12848S

SAG-d3
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

Cat. No.	Product Name		Classification

HY-RS12415

SAG Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SAG Human Pre-designed siRNA Set A contains three designed siRNAs for SAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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