2. Anti-infection
  3. HBV
  4. SAG-524

SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC50 0.92 and 1.4 nM, respectively.

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SAG-524 Chemical Structure

SAG-524 Chemical Structure

CAS No. : 2246696-89-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Based on 1 publication(s) in Google Scholar

SAG-524 Related Antibodies

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Description

SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC50 0.92 and 1.4 nM, respectively[1].

Molecular Weight

594.12

Formula

C30H32ClN5O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COCCN1CCN(CC1)C2=NC3=CC=C(C=C3S2)N4C=C(C(C=C4C5=CC(Cl)=C(C=C5)N6CCCC6)=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (168.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6832 mL 8.4158 mL 16.8316 mL
5 mM 0.3366 mL 1.6832 mL 3.3663 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6832 mL 8.4158 mL 16.8316 mL 42.0790 mL
5 mM 0.3366 mL 1.6832 mL 3.3663 mL 8.4158 mL
10 mM 0.1683 mL 0.8416 mL 1.6832 mL 4.2079 mL
15 mM 0.1122 mL 0.5611 mL 1.1221 mL 2.8053 mL
20 mM 0.0842 mL 0.4208 mL 0.8416 mL 2.1040 mL
25 mM 0.0673 mL 0.3366 mL 0.6733 mL 1.6832 mL
30 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.4026 mL
40 mM 0.0421 mL 0.2104 mL 0.4208 mL 1.0520 mL
50 mM 0.0337 mL 0.1683 mL 0.3366 mL 0.8416 mL
60 mM 0.0281 mL 0.1403 mL 0.2805 mL 0.7013 mL
80 mM 0.0210 mL 0.1052 mL 0.2104 mL 0.5260 mL
100 mM 0.0168 mL 0.0842 mL 0.1683 mL 0.4208 mL
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SAG-524 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAG-5242246696-89-7SAG524SAG 524HBVHepatitis B virusInhibitorHepG2.2.15HbsAginhibitorinhibit

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