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Isoforms Recommended:	SIRT3

Results for "

SIRT3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (9) Aurora Kinase (1) Autophagy (5) Bcl-2 Family (1) c-Myc (1) Calcium Channel (1) Dihydroorotate Dehydrogenase (2) Endogenous Metabolite (5) HIV (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) JAK (1) MDM-2/p53 (2) Methionine Adenosyltransferase (MAT) (1) Microtubule/Tubulin (1) PPAR (1) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (1) SGLT (2) Sirtuin (35) Small Interfering RNA (siRNA) (3) SOD (1) STAT (1) TNF Receptor (3)
By Research Areas:	Cancer (28) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (3) Metabolic Disease (8) Neurological Disease (9)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133998

SIRT-IN-3 1 Publications Verification	Sirtuin	Cancer
SIRT-IN-3 is a potent *SIRT* inhibitor, with an IC₅₀ of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC₅₀ of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) .

HY-N6675

Gardenia yellow	Sirtuin	Neurological Disease Cancer
Gardenia yellow is an active member of crocin, increases mRNA expression of *SIRT3*, and acts as an orally active antidepressant agent .

HY-163987

SIRT3 activator 2	Sirtuin	Neurological Disease
SIRT3 activator 2 (compound 2a) is a *SIRT3* activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has *SIRT3* dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner .

HY-158162

SIRT3 activator 1	Sirtuin	Cardiovascular Disease
SIRT3 activator 1 (Compound 5v) is a *SIRT3* activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases .

HY-RS12943

SIRT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SIRT3 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIRT3 Human Pre-designed siRNA Set A SIRT3 Human Pre-designed siRNA Set A

HY-RS12944

Sirt3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt3 Mouse Pre-designed siRNA Set A Sirt3 Mouse Pre-designed siRNA Set A

HY-RS12945

Sirt3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt3 Rat Pre-designed siRNA Set A Sirt3 Rat Pre-designed siRNA Set A

HY-161920

SIRT3-IN-1	Sirtuin Apoptosis	Cancer
SIRT3-IN-1 (compound 17f) is a *SIRT3* inhibitor, with IC₅₀ of 0.043 μM. SIRT3-IN-1 can be used in the research of acute leukemia (AML) .

HY-169051

SIRT-IN-5	Sirtuin	Cancer
SIRT-IN-5 is a *SIRT3* inhibitor, with an IC₅₀ value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ .

HY-162837

AURKA against 1	Aurora Kinase	Cancer
AURKA against 1 is an inhibitor of AURKA (IC₅₀ less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3 .

HY-139742

ADTL-SA1215	Sirtuin	Cancer
ADTL-SA1215 is a first-in-class specific small-molecule activator of *SIRT3* that modulates autophagy in triple negative breast cancer.

HY-158426

2-APQC	Sirtuin	Cardiovascular Disease
2-APQC is a *SIRT3* activator with the K_d value of 2.756 μM. 2-APQC improves heart failure in vitro and in vivo .

HY-N1511

Ganoderic acid D 1 Publications Verification	Sirtuin Apoptosis	Cancer
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of *SIRT3* and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-15145A

SRT 1720 dihydrochloride 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-15145

SRT 1720 monohydrochloride 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 monohydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-100578

AGK2 10+ Cited Publications	Sirtuin Apoptosis	Cancer
AGK2 is a selective *SIRT2* inhibitor with an IC₅₀ of 3.5 μM. AGK2 inhibits *SIRT1* and *SIRT3* with IC₅₀s of 30 and 91 μM, respectively.

HY-19758A

Sirtuin modulator 1	Sirtuin	Cancer
Sirtuin modulator 1 is a modulator of SIRTl, a homolog of *SIRT3*, with EC_1.5 of < 1 μM, extracted from patent WO 2010071853 A1, Compound No.4.

HY-163676

MI-217	Sirtuin Apoptosis	Cancer
MI-217 is a potent *SIRT3* inhibitor. MI-217 induces MDA-MB-231 apoptosis. MI-217 can be used in the study of breast cancer .

HY-N1511R

Ganoderic acid D (Standard)	Sirtuin Apoptosis	Cancer
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-10532

SRT 1720 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 is a selective activator of human *SIRT1* with an EC_1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC_1.5s of 37 μM and > 300 μM, respectively.

HY-108331

3-TYP Maximum Cited Publications 60 Publications Verification	Sirtuin Methionine Adenosyltransferase (MAT) Indoleamine 2,3-Dioxygenase (IDO)	Others
3-TYP is an inhibitor of *SIRT3* (IC₅₀: ~377 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases ^[3].

HY-124037

SRT 1460 3 Publications Verification	Sirtuin	Cancer
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues .

HY-123033A

Nicotinamide riboside chloride 10+ Cited Publications	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-103636

*PROTAC Sirt2 Degrader-1*	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a *Sirt2* degrader, composed of a highly potent and isotype-selective *Sirt2* inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM) .

HY-150568

SIRT1/2/3-IN-1	Sirtuin	Cancer
SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of *SIRT1, SIRT2* and *SIRT3* with IC₅₀s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer .

HY-123033B

Nicotinamide riboside tartrate	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Sirtuin Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033D

Nicotinamide riboside (triflate)	Endogenous Metabolite Sirtuin	Neurological Disease Metabolic Disease Cancer
Nicotinamide riboside (triflate), an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside (triflate) is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside (triflate) reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-15510

Tenovin-6 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-15510B

Tenovin-6 Hydrochloride 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-155729

Sirt1/2-IN-4	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC₅₀s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity .

HY-111303

CHIC35	Sirtuin	Neurological Disease Inflammation/Immunology
CHIC35, an analog of EX-527, is a potent and selective inhibitor of *SIRT1* (IC₅₀=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC₅₀=2.8 µM) or SIRT3 (IC₅₀>100 µM) . CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and *SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀* of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-100591

SirReal2 2 Publications Verification	Sirtuin	Neurological Disease Inflammation/Immunology Cancer
SirReal2 is a potent, isotype-selective *Sirt2* inhibitor with an IC₅₀ value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration ^[3] .

HY-111329

JGB1741 ILS-JGB-1741	Sirtuin Apoptosis	Cancer
JGB1741 (ILS-JGB-1741) is a potent and specific *SIRT1* activity inhibitor with an IC₅₀ of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC₅₀>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research .

HY-148712

SIRT6 activator 12q	Apoptosis Sirtuin	Cancer
SIRT6 activator 12q is potent, selective and orally active *SIRT6* activator with IC₅₀ values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity .

HY-111522

RK-9123016	Sirtuin c-Myc	Cancer
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC₅₀ value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression .

HY-N6850

Calenduloside E 1 Publications Verification	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR	Cardiovascular Disease Inflammation/Immunology
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the *AMPK-SIRT3* pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated *JAK1-STAT3* pathways to reduce cellular inflammatory responses ^[3] .

HY-118343

AC-93253	Sirtuin	Cancer
AC-93253 is a selective, potent *SIRT2* inhibitor. AC93253 can inhibit SIRT2 with an IC₅₀ value of 6 μM. AC93253 can be used for the research of tumors .

HY-N4100

Trilobatin 2 Publications Verification	TNF Receptor HIV SGLT	Infection
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd , Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope . Neuroprotective effects . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells ^[3].

HY-N4100R

Trilobatin (Standard)	TNF Receptor HIV SGLT	Infection
Trilobatin (Standard) is the analytical standard of Trilobatin. This product is intended for research and analytical applications. Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd , Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope . Neuroprotective effects . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells ^[3].

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Sirtuin
Gardenia yellow is an active member of crocin, increases mRNA expression of *SIRT3*, and acts as an orally active antidepressant agent .

Ganoderic acid D 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Sirtuin Apoptosis
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of *SIRT3* and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

Nicotinamide riboside chloride Maximum Cited Publications 13 Publications Verification	Alkaloids Structural Classification Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Metabolic Disease Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

Species:	Human (2) Mouse (1)
Tag:	His (2) SUMO (1) Tag Free (1) Myc (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701610

	SIRT3 Protein, Human (His, SUMO) SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human (His, SUMO) is the recombinant human-derived SIRT3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of SIRT3 Protein, Human (His, SUMO) is 282 a.a., .

HY-P702774

	SIRT3 Protein, Mouse (His, Myc) SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Mouse	E. coli
	SIRT3 Protein, Mouse (His, Myc) is the recombinant mouse-derived SIRT3, expressed by E. coli , with N-10*His, C-Myc labeled tag. ,

HY-P701609

	SIRT3 Protein, Human SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human is the recombinant human-derived SIRT3 protein, expressed by E. coli , with tag free. The total length of SIRT3 Protein, Human is 282 a.a., .

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HY-P80892

	SIRT3 Antibody SIR2L3	WB, IHC-P	Human
	SIRT3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to SIRT3. It can be used for WB,IHC-P assays with tag free, in the background of Human.

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