2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. AC-93253

AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors.

For research use only. We do not sell to patients.

AC-93253 Chemical Structure

AC-93253 Chemical Structure

CAS No. : 108527-83-9

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Based on 1 publication(s) in Google Scholar

AC-93253 Related Antibodies

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Description

AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].

IC50 & Target[1]

SIRT1

45.3 μM (IC50)

SIRT2

6 μM (IC50)

SIRT3

24.6 μM (IC50)

In Vitro

AC93253 can inhibit SIRT1, SIRT2 and SIRT3 with IC50 values of 45.3 μM, 6 μM and 24.6 μM, respectively[1].
AC-93253 (0, 2, 5, 10 μM; 16 h) significantly enhanced the acetylation of tubulin, p53, and histone H4[1].
AC-93253 exhibits selective cytotoxicity towards four tumor cell lines in a single agent with IC50 values ranging from 10 to 100 nM[1].
AC-93253 significantly triggered apoptosis [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AC-93253 Related Antibodies

Western Blot Analysis[1]

Cell Line: NCI-H460 cells, HeLa cells
Concentration: 0, 2, 5, 10 μM
Incubation Time: 16 h
Result: Increased the acetylation levels of a-tubulin in a dose-dependent manner.
Increased the level of histone protein and p53.
Molecular Weight

488.43

Formula

C23H25IN2S
CAS No.
SMILES

CC1(C)C2=C(C=CC=C2)N(C)/C1=C/C=C/C3=[N+](CC)C4=C(C=CC=C4)S3.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AC-93253 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-93253108527-83-9AC93253AC 93253SirtuinsirtuinsSIRT2SIRT1SIRT3tumorInhibitorinhibitorinhibit

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HY-118343
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