2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Sirtuin Endogenous Metabolite
  4. Nicotinamide riboside malate

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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Nicotinamide riboside malate Chemical Structure

Nicotinamide riboside malate Chemical Structure

CAS No. : 2415659-01-5

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Other Forms of Nicotinamide riboside malate:

Nicotinamide riboside malate Related Antibodies

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Description

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

In Vitro

Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide riboside malate Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 mM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo

Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
Clinical Trial
Molecular Weight

388.33

Formula

C15H20N2O10
CAS No.
SMILES

NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.O[C@H](C(O)=O)CC([O-])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nicotinamide riboside malate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicotinamide riboside2415659-01-5SirtuinEndogenous MetaboliteNAD+oxidativemetabolismmetabolicabnormalitiesdietarysupplementsorallyvitaminB3niacinAlzheimer’sCOVID-19PARPInhibitorinhibitorinhibit

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