2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. Sirtuin Microtubule/Tubulin
  4. Sirt1/2-IN-1

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.

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Sirt1/2-IN-1 Chemical Structure

Sirt1/2-IN-1 Chemical Structure

CAS No. : 2402779-21-7

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Sirt1/2-IN-1 Related Antibodies

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Description

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

IC50 & Target

SIRT1

1.81 μg/mL (IC50)

SIRT2

2.10 μg/mL (IC50)

SIRT3

20.5 μg/mL (IC50)

Molecular Weight

420.93

Formula

C22H13ClN2OS2
CAS No.
SMILES

O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21
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Purity & Documentation
References
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Sirt1/2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirt1/2-IN-12402779-21-7SirtuinMicrotubule/TubulinMCF-7UO-31anticancerα-tubulin protein acetylationInhibitorinhibitorinhibit

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