Sirt1/2-IN-1

Cat. No.: HY-146013: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀ of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.

For research use only. We do not sell to patients.

Sirt1/2-IN-1 Chemical Structure

CAS No. : 2402779-21-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Sirtuin Isoform Specific Products:

View All Isoforms

Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

SIRT1

1.81 μg/mL (IC₅₀)

SIRT2

2.10 μg/mL (IC₅₀)

SIRT3

20.5 μg/mL (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	2.34 μg/mL Compound: 7	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31812033]
UO-31	IC₅₀	12.41 μg/mL Compound: 7	Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human UO31 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31812033]

Molecular Weight

420.93

Formula

C₂₂H₁₃ClN₂OS₂

CAS No.

2402779-21-7

SMILES

O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926. [Content Brief]

Sirt1/2-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirt1/2-IN-12402779-21-7SirtuinMicrotubule/TubulinMCF-7UO-31anticancerα-tubulin protein acetylationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks