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Results for "

TMP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Caspase (1) Cholinesterase (ChE) (1) DNA Alkylator/Crosslinker (1) Endogenous Metabolite (2) G-quadruplex (1) HDAC (2) Isotope-Labeled Compounds (1) P2Y Receptor (1) Phosphodiesterase (PDE) (1) ROR (3) SARS-CoV (2) Telomerase (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (4) Metabolic Disease (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1157

Trioxsalen 2 Publications Verification Trisoralen; Trioxysalen; TMP	DNA Alkylator/Crosslinker	Inflammation/Immunology
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .

HY-117819

TMP920	ROR	Inflammation/Immunology
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC₅₀ of 0.03 μM .

HY-102075A

TMP778	ROR	Inflammation/Immunology
TMP778 is a potent and selevtive RORγt inverse agonist, with an IC₅₀ of 7 nM in FRET assay.

HY-102075B

TMP780	ROR	Inflammation/Immunology
TMP780 is an inverse agonist of RORγt with an IC₅₀ of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders .

HY-18361

TMP195 Maximum Cited Publications 13 Publications Verification	HDAC	Cancer
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with K_is of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

HY-18360

TMP269 10+ Cited Publications	HDAC	Cancer
TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC₅₀s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

HY-108477

TMPyP4 tosylate 2 Publications Verification TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .

HY-124064

TMP-153	Acyltransferase	Metabolic Disease
TMP-153 is an orally active inhibitor of ACAT with an IC₅₀ value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .

HY-150265

TNH TMP-NVOC linker-Halo	Others	Others
TNH is a dimer that can enter living cells and recruit proteins into cellular structures .

HY-128738S

Thymidine-5'-monophosphate-13C10,15N2 disodium TMP-¹³C₁₀,¹⁵N₂	Endogenous Metabolite	Metabolic Disease
Thymidine-5'-monophosphate- ¹³C₁₀, ¹⁵N₂ (disodium) is the ¹³C and ¹⁵N labeled Thymidine-5'-monophosphate disodium salt[1]. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.

HY-153890

*NVOC cage-TMP-Halo*	Others	Others
NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-131821

5'-TMPS Thymidine-5'-O-monophosphorothioate	P2Y Receptor	Others
5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y₆R and an antagonist of P2Y₁₄R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects

HY-N12033

4'-Demethylpodophyllotoxone	Others	Cancer
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

HY-N2044

Methyl 3,4,5-trimethoxybenzoate	Others	Others
Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.

HY-162698

JMF4073	Thymidylate Synthase	Cancer
JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC₅₀s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo .

HY-137807

Thymidine 5′-monophosphate p-nitrophenyl ester sodium	Endogenous Metabolite	Cancer
Thymidine 5′-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5′-monophosphate p-nitrophenyl ester sodium penetrates mammalian cells, releases intracellular antimetabolite 5' nucleotides. Thymidine 5′-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug .

HY-139362

Enpp-1-IN-2	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC₅₀ values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe .

HY-N2044S

Methyl 3,4,5-trimethoxybenzoate-d9	Isotope-Labeled Compounds	Others
Methyl 3,4,5-trimethoxybenzoate-d₉ is the deuterium labeled Methyl 3,4,5-trimethoxybenzoate[1]. Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents[2].

Cat. No.	Product Name	Target	Research Area

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2044

Methyl 3,4,5-trimethoxybenzoate	Apocynaceae Structural Classification Natural Products Rauvolfia serpentina Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents.

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-N12033

4'-Demethylpodophyllotoxone	Structural Classification Source classification Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae	Others
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

Cat. No.	Compare	Product Name	Species	Source

HY-P77250

	TMP21/p23 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 10; TMED10; S31I125; p24delta; TMP-21-I	Human	HEK293
	TMP21/p23 proteins act as cargo receptors in endoplasmic reticulum (ER) and Golgi vesicle trafficking, mediating quality control. TMP21/p23 Protein, Human (HEK293, Fc) is the recombinant human-derived TMP21/p23 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMP21/p23 Protein, Human (HEK293, Fc) is 154 a.a., with molecular weight of ~44 KDa.

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Cat. No.	Product Name	Chemical Structure

HY-128738S

Thymidine-5'-monophosphate-13C10,15N2 disodium
Thymidine-5'-monophosphate- ¹³C₁₀, ¹⁵N₂ (disodium) is the ¹³C and ¹⁵N labeled Thymidine-5'-monophosphate disodium salt[1]. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.

HY-N2044S

Methyl 3,4,5-trimethoxybenzoate-d9
Methyl 3,4,5-trimethoxybenzoate-d₉ is the deuterium labeled Methyl 3,4,5-trimethoxybenzoate[1]. Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents[2].

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TMP

Inhibitors & Agonists

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