Thymidine 5′-monophosphate p-nitrophenyl ester sodium

Cat. No.: HY-137807 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Thymidine 5′-monophosphate p-nitrophenyl ester sodium (Compound 2a) is the derivative of thymidine 5'-phosphate (TMP). Thymidine 5′-monophosphate p-nitrophenyl ester sodium penetrates mammalian cells, releases intracellular antimetabolite 5' nucleotides. Thymidine 5′-monophosphate p-nitrophenyl ester sodium is potential as an antitumor prodrug.

For research use only. We do not sell to patients.

Thymidine 5′-monophosphate p-nitrophenyl ester sodium Chemical Structure

CAS No. : 98179-10-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

465.28

Formula

C₁₆H₁₇N₃NaO₁₀P

CAS No.

98179-10-3

Appearance

Solid

Color

White to yellow

SMILES

O=C(N1)N([C@@H]2O[C@H](COP(OC3=CC=C([N+]([O-])=O)C=C3)(O[Na])=O)[C@@H](O)C2)C=C(C)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 116.67 mg/mL (250.75 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1492 mL	10.7462 mL	21.4924 mL
5 mM	0.4298 mL	2.1492 mL	4.2985 mL
10 mM	0.2149 mL	1.0746 mL	2.1492 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB) HNMR (269 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Chawla RR, et al., Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in mouse cells in culture. J Med Chem. 1984 Dec;27(12):1733-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1492 mL	10.7462 mL	21.4924 mL	53.7311 mL
	5 mM	0.4298 mL	2.1492 mL	4.2985 mL	10.7462 mL
	10 mM	0.2149 mL	1.0746 mL	2.1492 mL	5.3731 mL
	15 mM	0.1433 mL	0.7164 mL	1.4328 mL	3.5821 mL
	20 mM	0.1075 mL	0.5373 mL	1.0746 mL	2.6866 mL
	25 mM	0.0860 mL	0.4298 mL	0.8597 mL	2.1492 mL
	30 mM	0.0716 mL	0.3582 mL	0.7164 mL	1.7910 mL
	40 mM	0.0537 mL	0.2687 mL	0.5373 mL	1.3433 mL
	50 mM	0.0430 mL	0.2149 mL	0.4298 mL	1.0746 mL
	60 mM	0.0358 mL	0.1791 mL	0.3582 mL	0.8955 mL
	80 mM	0.0269 mL	0.1343 mL	0.2687 mL	0.6716 mL
	100 mM	0.0215 mL	0.1075 mL	0.2149 mL	0.5373 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.