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NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research.

For research use only. We do not sell to patients.

NVOC cage-TMP-Halo Chemical Structure

NVOC cage-TMP-Halo Chemical Structure

CAS No. : 2137894-98-3

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1 mg USD 60 In-stock
5 mg USD 170 In-stock
10 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

NVOC cage-TMP-Halo Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research[1].

In Vitro

NVOC cage-TMP-Halo (20μM, 60 min) exhibited dramatic recruitment of mCherry-eDHFR to centromeres with a t1/2 of ~ 15 s of expressing CENPB-GFP-Haloenzyme and mCherry-eDHFR HeLa cell line[1].
NVOC cage-TMP-Halo (20μM, 15, 30, and 60 min) has the power for spatially precise manipulation of protein localization in HeLa cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NVOC cage-TMP-Halo Related Antibodies
Molecular Weight

878.36

Formula

C40H56ClN7O13
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C(OC)C=C(COC(NC2=NC(N)=C(CC3=CC(OC)=C(OCCCNC(CCC(NCCOCCOCCCCCCCl)=O)=O)C(OC)=C3)C=N2)=O)C([N+]([O-])=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (170.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1385 mL 5.6924 mL 11.3849 mL
5 mM 0.2277 mL 1.1385 mL 2.2770 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1385 mL 5.6924 mL 11.3849 mL 28.4621 mL
5 mM 0.2277 mL 1.1385 mL 2.2770 mL 5.6924 mL
10 mM 0.1138 mL 0.5692 mL 1.1385 mL 2.8462 mL
15 mM 0.0759 mL 0.3795 mL 0.7590 mL 1.8975 mL
20 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.4231 mL
25 mM 0.0455 mL 0.2277 mL 0.4554 mL 1.1385 mL
30 mM 0.0379 mL 0.1897 mL 0.3795 mL 0.9487 mL
40 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.7116 mL
50 mM 0.0228 mL 0.1138 mL 0.2277 mL 0.5692 mL
60 mM 0.0190 mL 0.0949 mL 0.1897 mL 0.4744 mL
80 mM 0.0142 mL 0.0712 mL 0.1423 mL 0.3558 mL
100 mM 0.0114 mL 0.0569 mL 0.1138 mL 0.2846 mL
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NVOC cage-TMP-Halo Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVOC cage-TMP-Halo2137894-98-3Othersprotein dimerizationcellsInhibitorinhibitorinhibit

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