JMF4073

Cat. No.: HY-162698: FAQs
Data Sheet Handling Instructions

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JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC₅₀s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo.

For research use only. We do not sell to patients.

JMF4073 Chemical Structure

CAS No. : 1927930-61-7

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Description

In Vitro

WT-Bcr-Abl cells are highly susceptible to JMF4073 with GI₅₀ 0.67 μM as compared to 1.5 μM and 4.2 μM for T315I-Bcr-Abl-32D and untransformed 32D cells, respectively. The levels of overall tyrosine phosphorylation in these cells were unaffected by JMF4073 treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JMF4073 (5 mg/kg; ip; daily; for 14 days) inhibits white blood counts in WT-Bcr-Abl-32D bearing mice. Moreover, JMF4073 prolongs the survival of leukemia mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C3H/HeNCrNarl mice injected with WT-Bcr-Abl-32D chronic myeloid leukemia (CML) cells^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily; for 14 days
Result:	Prolonged the survival of leukemia mice.

Molecular Weight

395.45

Formula

C₁₈H₂₂FN₃O₄S

CAS No.

1927930-61-7

SMILES

FC1=CC=C(SN(CC(N2CCN(C(OC(C)(C)C)=O)CC2)=O)C3=O)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chang-Yu Huang, et al. Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK. Commun Biol. 2024 Jul 10;7(1):843. [Content Brief]

JMF4073 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMF40731927930-61-7JMF 4073JMF-4073Thymidylate Synthasecytidylate kinasesmyeloid leukemia,Inhibitorinhibitorinhibit

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