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ZX-782

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161972
    ZX782

    		PROTACs Glutathione Peroxidase Ferroptosis Cancer
    ZX782 is a Hty-type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination . ZX782 is composed of target protein ligand (red part) ML-210 (HY-100003), PROTAC linker (black part) Bromo-PEG2-CH2-Boc (HY-141371) and Hty molecule (blue part) Adamantan-1-ylmethanamine (HY-W037848). The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br (HY-161974), and the activity control of the target protein ligand is Hydroxyl-ML-210 (HY-161973).
    ZX782
  • HY-161973
    Hydroxyl-ML-210

    		Ligands for Target Protein for PROTAC Cancer
    Hydroxyl-ML-210 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Hydroxyl-ML-210 can be used for synthesis ZX782 (HY-161972) .
    Hydroxyl-ML-210
  • HY-W037848
    Adamantan-1-ylmethanamine

    1-Aminomethyladamantane

    		 Others Cancer
    Adamantan-1-ylmethanamine (1-Aminomethyladamantane) is a Hyt hydrophobic group. Adamantan-1-ylmethanamine can be used in the synthesis of ZX782 (HY-161972) .
    Adamantan-1-ylmethanamine
  • HY-161974
    Adamantan-C-amide-PEG2-C-Br

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Adamantan-C-amide-PEG2-C-Br is a conjugate of a Hyt hydrophobic group and a linker. Adamantan-C-amide-PEG2-C-Br can be used to synthesize ZX782 (HY-161972) .
    Adamantan-C-amide-PEG2-C-Br

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