2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. ZX782

ZX782 is a GPX4 protein degrader and ferroptosis inducer, which consumes GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways. After GPX4 degradation induced by ZX782, it can significantly increase the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.

For research use only. We do not sell to patients.

ZX782 Chemical Structure

ZX782 Chemical Structure

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Description

ZX782 is a GPX4 protein degrader and ferroptosis inducer, which consumes GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways. After GPX4 degradation induced by ZX782, it can significantly increase the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells[1].

Molecular Weight

750.28

Formula

C39H48ClN5O8
SMILES

O=C(C1=NOC(C)=C1[N+]([O-])=O)N2CCN(C(C3=CC=C(OCCOCCOCC(NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4)=O)C=C3)C7=CC=C(Cl)C=C7)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZX782 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZX782ZX 782ZX-782Glutathione PeroxidaseFerroptosisInhibitorinhibitorinhibit

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