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Results for "

cardioprotective agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (1) COX (1) Epoxide Hydrolase (1) Ferroptosis (2) Fungal (1) Lipoxygenase (1) Mitochondrial Metabolism (3) Necroptosis (1) Potassium Channel (5) RXFP Receptor (1) Sodium Channel (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (21) Infection (1) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0581

Dexrazoxane Maximum Cited Publications 10 Publications Verification ICRF-187; ADR-529; NSC-169780	Ferroptosis Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .

HY-126653

Atpenin A5 2 Publications Verification	Potassium Channel	Cardiovascular Disease
Atpenin A5 is a potent and highly specific complex II inhibitor (IC₅₀ ~10 nM), and is an effective mK_ATP channel agonist and cardioprotective agent .

HY-14290

Pinacidil 4 Publications Verification P-1134	Potassium Channel	Cardiovascular Disease
Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K ⁺-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy .

HY-113841

RS-87337	Others	Cardiovascular Disease
RS-87337 is an orally active antiarrhythmic agent that increases the duration and the maximum rate of rise of cardiac muscle action potentials. RS-87337 is promising for research of antiarrhythmic and cardioprotective agents .

HY-16213

FURNIDIPINE CRE 319	Others	Cardiovascular Disease
FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects .

HY-N12019

Parishin K	Biochemical Assay Reagents	Cardiovascular Disease
Parishin K is a cardioprotective agent obtained from the roots of Gastrodia elata Bl. Parishin K can be used in cardiovascular disease research .

HY-119306

MCC-134	Potassium Channel	Cardiovascular Disease
MCC-134, a blocker of mitochondrial and opener of surface ATP-sensitive K+ (K_ATP) channels, abrogates cardioprotective effects of chronic hypoxia. MCC-134 is a vasorelaxing agent .

HY-121710

MonoHER 7-Monohydroxyethylrutoside	Others	Cardiovascular Disease
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .

HY-122212

PF-9404C	Adrenergic Receptor	Cardiovascular Disease
PF-9404C is a potent beta-adrenergic blocker and a vasorelaxing agent. PF-9404C can be used as NO-donor. PF-9404C shows antihypertensive and cardioprotective action .

HY-19463A

F15845	Sodium Channel	Cardiovascular Disease
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .

HY-110312

JTV-519 fumarate K201 fumarate	Others	Cardiovascular Disease
JTV-519 fumarate (K201 fumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects .

HY-14290R

Pinacidil (Standard)	Potassium Channel	Cardiovascular Disease
Pinacidil (Standard) is the analytical standard of Pinacidil. This product is intended for research and analytical applications. Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K ⁺-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy .

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-N0794

Proanthocyanidins 3 Publications Verification	Bacterial Fungal	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

HY-108351

IM-54	Necroptosis	Cardiovascular Disease
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H₂O₂-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death .

HY-B1836

Meldonium 2 Publications Verification MET-88; Quaterin	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor .

HY-B1836A

Meldonium dihydrate 2 Publications Verification MET-88 dihydrate; Quaterin dihydrate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Metabolic Disease
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor .

HY-B0581R

Dexrazoxane (Standard)	Ferroptosis Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane (Standard) is the analytical standard of Dexrazoxane. This product is intended for research and analytical applications. Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .

HY-P10728

B7-33	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects .

HY-B1836AR

Meldonium dihydrate (Standard)	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Metabolic Disease
Meldonium (dihydrate) (Standard) is the analytical standard of Meldonium (dihydrate). This product is intended for research and analytical applications. Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor .

HY-121586

Nafazatrom Bay g 6575	Others	Cardiovascular Disease
Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro .

HY-159169

5-LOX/sEH-IN-1	COX Epoxide Hydrolase Lipoxygenase	Inflammation/Immunology
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC₅₀ values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC₅₀=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .

Cat. No.	Product Name	Target	Research Area

HY-P10728

B7-33	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects .

Proanthocyanidins 3 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Infection Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Bacterial Fungal
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

Parishin K	Structural Classification Gastrodia elata Bl. Orchidaceae Source classification Plants Saccharides Monosaccharides	Biochemical Assay Reagents
Parishin K is a cardioprotective agent obtained from the roots of Gastrodia elata Bl. Parishin K can be used in cardiovascular disease research .

Cat. No.	Product Name		Classification

HY-159169

5-LOX/sEH-IN-1		Azide
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC₅₀ values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC₅₀=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .

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cardioprotective agent

Inhibitors & Agonists

Peptides

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Click Chemistry

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