B7-33 

B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects^[1][2].

2986.54

C₁₃₁H₂₂₉N₄₁O₃₆S

1818415-56-3

Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu-NH2

VIKLSGRELVRAQIAISGMSTWSKRSL-NH2

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)[C@H](CC)C)=O)CCCCN)=O)CC(C)C)=O)CO)=O)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)C)=O)[C@H](CC)C)=O)CO)=O)=O)CCSC)=O)CO)=O)[C@@H](C)O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCCN)=O)CO)=O)C=1C=2C(NC1)=CC=CC2

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• [1]. Alam F, et al. The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. Biomed Pharmacother. 2023 Apr;160:114370.  [Content Brief]

  [2]. Hossain MA, et al. A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem Sci. 2016 Jun 1;7(6):3805-3819.  [Content Brief]