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Results for "

hearing

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Apoptosis (1) Ferroptosis (1) Gap Junction Protein (1) Neurokinin Receptor (1) Neurotensin Receptor (1) Phosphatase (1) Potassium Channel (1) Src (1) γ-secretase (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (2) Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss .

HY-B0019C

(R)-Azasetron besylate SENS-401	Phosphatase	Cancer
(R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate reduces Cisplatin (HY-17394)-induced hearing loss and cochlear damage .

HY-18237

KX1-004	Src	Others
KX1-004 is a potent and non-ATP competitive Src-PTK inhibitor with an IC₅₀ of 40 μM. KX1-004 protects the cochlea from hazardous noise and prevents noise-induced hearing loss (NIHL) .

HY-148650A

(R)-Sortilin antagonist 1	Neurotensin Receptor	Neurological Disease
(R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 can be used in the study of hearing loss .

HY-153746

Kv3 modulator 5	Potassium Channel	Neurological Disease
Kv3 modulator 5 (Example 5) is a Kv3 channel modulator. Kv3 modulator 5 increases the Kv3.2 current. Kv3 modulator 5 can be used for research of hearing disorders .

HY-120726

BF844	Others	Others
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1) ^N48K. BF844 induces CLRN1 ^N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo .

HY-149318

VRT-534	Gap Junction Protein	Others
VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC₅₀ value of 19 μM and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment .

HY-163506

Ebselen derivative 1	Apoptosis Ferroptosis	Others
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .

HY-158012

LY3056480	γ-secretase	Others
LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals .

HY-B0612B

(S)-Lercanidipine	Others	Neurological Disease
(S)-Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S)-Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S)-Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S)-Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S)-Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S)-Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S)-Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism .

HY-18673

PROTO-1	Others	Others
PROTO-1 is a hair cell protector and can be used in studies of ototoxicity-induced hair cell death .

HY-128064

Adenosine amine congener ADAC	Adenosine Receptor	Neurological Disease Inflammation/Immunology
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects .

Cat. No.	Product Name	Type

HY-121892

(Z)-KC02	Drug Delivery
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

(Z)-KC02

Drug Delivery

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P5163

NMB-1	Peptides	Inflammation/Immunology
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC₅₀: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain .

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