(R)-Azasetron besylate (Synonyms: SENS-401)

Name: (R)-Azasetron besylate
Brand: MedChemExpress
SKU: HY-B0019C
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0019C Purity: 98.78%: FAQs
Data Sheet SDS COA Handling Instructions

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(R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate reduces Cisplatin (HY-17394)-induced hearing loss and cochlear damage.

For research use only. We do not sell to patients.

(R)-Azasetron besylate Chemical Structure

CAS No. : 2025360-91-0

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5 mg	USD 147	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 236	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 472	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 755	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1208	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Azasetron besylate:

Azasetron Get quote

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Description

(R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate reduces Cisplatin (HY-17394)-induced hearing loss and cochlear damage^[1]^[2].

Molecular Weight

507.99

Formula

C₂₃H₂₆ClN₃O₆S

CAS No.

2025360-91-0

Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(C1=CC=CC=C1)=O.O=C(C2=C(OCC(N3C)=O)C3=CC(Cl)=C2)N[C@H]4CN5CCC4CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (393.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9685 mL	9.8427 mL	19.6854 mL
5 mM	0.3937 mL	1.9685 mL	3.9371 mL
10 mM	0.1969 mL	0.9843 mL	1.9685 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 20 mg/mL (39.37 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 20 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (200.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 20 mg/mL (39.37 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 20 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (200.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 20 mg/mL (39.37 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 20 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (200.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.78%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) HNMR (124 KB) RP-HPLC (153 KB) LCMS (238 KB)

Handling Instructions (2659 KB)

References

[1]. Petremann M, et al. SENS-401 Effectively Reduces Severe Acoustic Trauma-Induced Hearing Loss in Male Rats With Twice Daily Administration Delayed up to 96 hours. Otol Neurotol. 2019 Feb;40(2):254-263. [Content Brief]

[2]. Petremann M, et al. Oral Administration of Clinical Stage Drug Candidate SENS-401 Effectively Reduces Cisplatin-induced Hearing Loss in Rats. Otol Neurotol. 2017 Oct;38(9):1355-1361. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9685 mL	9.8427 mL	19.6854 mL	49.2136 mL
	5 mM	0.3937 mL	1.9685 mL	3.9371 mL	9.8427 mL
	10 mM	0.1969 mL	0.9843 mL	1.9685 mL	4.9214 mL
	15 mM	0.1312 mL	0.6562 mL	1.3124 mL	3.2809 mL
	20 mM	0.0984 mL	0.4921 mL	0.9843 mL	2.4607 mL
	25 mM	0.0787 mL	0.3937 mL	0.7874 mL	1.9685 mL
	30 mM	0.0656 mL	0.3281 mL	0.6562 mL	1.6405 mL
	40 mM	0.0492 mL	0.2461 mL	0.4921 mL	1.2303 mL
	50 mM	0.0394 mL	0.1969 mL	0.3937 mL	0.9843 mL
	60 mM	0.0328 mL	0.1640 mL	0.3281 mL	0.8202 mL
	80 mM	0.0246 mL	0.1230 mL	0.2461 mL	0.6152 mL
	100 mM	0.0197 mL	0.0984 mL	0.1969 mL	0.4921 mL

(R)-Azasetron besylate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Azasetron besylate2025360-91-0SENS-401SENS401SENS 401PhosphatasecancercalcineurinCisplatinhearing losscochlear damageInhibitorinhibitorinhibit

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(R)-Azasetron besylate (Synonyms: SENS-401)

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Complete Stock Solution Preparation Table

(R)-Azasetron besylate Related Classifications

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