(S)-Lercanidipine 

(S)-Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S)-Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S)-Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S)-Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S)-Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S)-Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S)-Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism^[1].

611.73

C₃₆H₄₁N₃O₆

185197-71-1

O=C(OC(C)(CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=C2)C)C3=C(NC(C)=C([C@@H]3C4=CC=CC([N+]([O-])=O)=C4)C(OC)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lercanidipine's Antioxidative Effect Prevents Noise-Induced Hearing Loss