Ebselen derivative 1 

Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss ^[1].

Ebselen derivative 1 (Compound 19) (100 μM) significantly reduces cisplatin (HY-17394) -induced apoptosis and ferroptosis in hair cells and alleviates the surge of oxidative stress triggered by cisplatin throughout the cochlea ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ebselen derivative 1 (Compound 19) (80 mg/kg; oral administration; once daily for one week) exhibites hearing protective effects in C57BL/6 mice, mitigating the hair cell loss induced by cisplatin (5 mg/kg; i.p.; administered once on the third and seventh days of Ebselen derivative 1 treatment) (HY-17394)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

305.19

C₁₃H₁₀N₂O₂Se

3030492-59-9

O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404.  [Content Brief]