1. Apoptosis
  2. Apoptosis Ferroptosis
  3. Ebselen derivative 1

Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .

For research use only. We do not sell to patients.

Ebselen derivative 1 Chemical Structure

Ebselen derivative 1 Chemical Structure

CAS No. : 3030492-59-9

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Description

Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1].

In Vitro

Ebselen derivative 1 (Compound 19) (100 μM) significantly reduces cisplatin (HY-17394) -induced apoptosis and ferroptosis in hair cells and alleviates the surge of oxidative stress triggered by cisplatin throughout the cochlea [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ebselen derivative 1 (Compound 19) (80 mg/kg; oral administration; once daily for one week) exhibites hearing protective effects in C57BL/6 mice, mitigating the hair cell loss induced by cisplatin (5 mg/kg; i.p.; administered once on the third and seventh days of Ebselen derivative 1 treatment) (HY-17394)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

305.19

Formula

C13H10N2O2Se

CAS No.
SMILES

O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2

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Ebselen derivative 1 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ebselen derivative 1
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HY-163506
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