Search Result

Results for "

monovalent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Androgen Receptor (1) Antibiotic (7) Apoptosis (5) Bacterial (8) Biochemical Assay Reagents (1) c-Met/HGFR (1) CDK (1) DNA Alkylator/Crosslinker (1) Epigenetic Reader Domain (3) Fungal (4) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) HSP (1) Influenza Virus (1) Mitochondrial Metabolism (1) Molecular Glues (2) Na+/H+ Exchanger (NHE) (1) Na+/K+ ATPase (1) NF-κB (1) Oxidative Phosphorylation (2) Parasite (1) Potassium Channel (1) Reactive Oxygen Species (1) Wnt (1)
By Research Areas:	Cancer (14) Infection (9) Inflammation/Immunology (1)

By Targets:

ADC Linker (2)

Androgen Receptor (1)

Antibiotic (7)

Apoptosis (5)

Bacterial (8)

Biochemical Assay Reagents (1)

c-Met/HGFR (1)

CDK (1)

DNA Alkylator/Crosslinker (1)

Epigenetic Reader Domain (3)

Fungal (4)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (1)

HSP (1)

Influenza Virus (1)

Mitochondrial Metabolism (1)

Molecular Glues (2)

Na+/H+ Exchanger (NHE) (1)

Na+/K+ ATPase (1)

NF-κB (1)

Oxidative Phosphorylation (2)

Parasite (1)

Potassium Channel (1)

Reactive Oxygen Species (1)

Wnt (1)

By Research Areas:

Cancer (14)

Infection (9)

Inflammation/Immunology (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139813

Phenanthriplatin	DNA Alkylator/Crosslinker	Cancer
Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .

HY-W111581

Copper(II) diethyldithiocarbamate Diethyldithiocarbamic acid copper salt	Others	Cancer
Copper(II) diethyldithiocarbamate has anticancer activity. Copper(II) diethyldithiocarbamate can be synthesized from monovalent copper-cysteamine and disulfiram .

HY-W025784

Kalibor Sodium tetraphenylborate; Tetraphenylboron sodium	Biochemical Assay Reagents	Others
Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .

HY-P99250

Onartuzumab 1 Publications Verification MetMAb	c-Met/HGFR	Cancer
Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-129525

Sulfo-SIAB	ADC Linker	Cancer
Sulfo-SIAB is a nonclaevable monovalent bilinker.

HY-129525A

Sulfo-SIAB sodium	ADC Linker	Cancer
Sulfo-SIAB sodium is a nonclaevable monovalent bilinker.

HY-163640

CDK4 degrader 1	CDK	Cancer
CDK4 degrader 1 (ML 1–71) is a monovalent degrader targeting CDK4 .

HY-111525

Monactin	Oxidative Phosphorylation Bacterial Antibiotic	Infection
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-163641

AR Degrader-1	Androgen Receptor	Cancer
AR Degrader-1 is an androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR without obvious cytotoxicity in LNCaP prostate cancer cells .

HY-A0068

Aurothioglucose 1 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-163638

BRD4 degrader-1	Molecular Glues Epigenetic Reader Domain	Cancer
BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue BRD4 degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .

HY-N4302

Monensin Monensin A	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt	Infection Cancer
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-P2324

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-17409

Nystatin Maximum Cited Publications 25 Publications Verification	Fungal Antibiotic Apoptosis Bacterial	Infection
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-P2324A

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-N6790

Nonactin Ammonium ionophore I	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP	Infection Cancer
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60 .

HY-163639

BRD4 degrader-2	Molecular Glues Epigenetic Reader Domain	Cancer
BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .

HY-P10228

S-Thanatin	Fungal Bacterial	Infection
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na ⁺/K ⁺) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .

HY-17409R

Nystatin (Standard)	Fungal Antibiotic Apoptosis Bacterial	Infection
Nystatin (Standard) is the analytical standard of Nystatin. This product is intended for research and analytical applications. Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-161779

PLX-3618	Epigenetic Reader Domain Apoptosis	Cancer
PLX-3618 is a monovalent direct degrader for BRD4 with DC₅₀ of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models .

Cat. No.	Product Name	Type