2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Onartuzumab

Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 1133766-06-9

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Onartuzumab Related Antibodies

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Description

Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Onartuzumab acts specifically by blocking HGF α-chain (but not β-chain) binding to MET[1].
Onartuzumab blocks HGF binding to human c-Met with an inhibitory concentration (IC)50 of 1.8 nM and inhibits the subsequent induction of c-Met auto-phosphorylation and cell proliferation in many cancer cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Onartuzumab Related Antibodies
In Vivo

Onartuzumab (30 mg/kg, IP, twice a week for 2 mouth) suppresses tumor growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human HGF-transgenic SCID mice implanted with BxPC3 tumor cells, nude (nu/nu) mice implanted with KP4 human pancreatic xenograft tumor cells[3]
Dosage: 30 mg/kg
Administration: IP, twice a week for 2 mouth
Result: Suppressed tumor growth, but did not affect the mean in vivo human HGF levels.
Animal Model: U-87 MG tumor-bearing mice[3]
Dosage: 30 mg/kg
Administration: IP, once
Result: Resulted in profound TGI (tumor growth inhibition) with 4/10 mice demonstrating a partial response (>50% reduction in tumor size) and 6/10 mice demonstrating a complete response (100% tumor regression).
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Onartuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (Fab-G1-kappa)-(Fc-G1)
Biological Activity
  • Immobilized Onartuzumab can bind Human c-MET/HGFR Protein (ECD, His Tag). The EC50 for this effect is 4.21 ng/mL.
Purity & Documentation
References
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Onartuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Onartuzumab1133766-06-9MetMAbc-Met/HGFRHeLa cellsMETePPNDplacentacynomolgus monkeyU-87BxPC3 tumorInhibitorinhibitorinhibit

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