2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis
  4. PLX-3618

PLX-3618 is a monovalent direct degrader for BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models.

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PLX-3618 Chemical Structure

PLX-3618 Chemical Structure

CAS No. : 2851986-76-8

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Description

PLX-3618 is a monovalent direct degrader for BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models[1].

Molecular Weight

601.68

Formula

C32H27N9O2S
CAS No.
SMILES

O=C(N)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(C5=CC=CC(NC(C6=C7N(C=CC=N7)N=C6)=O)=C5)C=C4)=N1
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PLX-3618 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLX-36182851986-76-8PLX3618PLX 3618Epigenetic Reader DomainApoptosisAMLMV-4-11NOD-SCID mouseInhibitorinhibitorinhibit

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