2. PROTAC Epigenetics Metabolic Enzyme/Protease
  3. Molecular Glues Epigenetic Reader Domain E1/E2/E3 Enzyme
  4. BRD4 degrader-2

BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells.

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BRD4 degrader-2 Chemical Structure

BRD4 degrader-2 Chemical Structure

CAS No. : 3036530-43-2

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BRD4 degrader-2 Related Antibodies

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Description

BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].

IC50 & Target[1]

BRD4

 

Molecular Weight

657.18

Formula

C34H33ClN6O4S
CAS No.
SMILES

ClC1=CC=C(C2=N[C@@H](CC(N3CCN(C(/C=C/C(C4=CC=C(OC)C=C4)=O)=O)CC3)=O)C5=NN=C(C)N5C6=C2C(C)=C(C)S6)C=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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BRD4 degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 degrader-23036530-43-2Molecular GluesEpigenetic Reader DomainE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasemolecular glueInhibitorinhibitorinhibit

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