2. Metabolic Enzyme/Protease Anti-infection
  3. Oxidative Phosphorylation Bacterial Antibiotic
  4. Monactin

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.

For research use only. We do not sell to patients.

Monactin Chemical Structure

Monactin Chemical Structure

CAS No. : 7182-54-9

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Based on 1 publication(s) in Google Scholar

Monactin Related Antibodies

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Description

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

In Vitro

Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Monactin Related Antibodies
In Vivo

Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

750.96

Formula

C41H66O12
CAS No.
SMILES

CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3C)=O)C)CC5)C)=O)C)([H])CC4
Structure Classification
Initial Source

Streptomyces griseus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Monactin Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monactin7182-54-9Oxidative PhosphorylationBacterialAntibiotictranscriptionalmactrotetralideionophorecationsantiproliferativeInhibitorinhibitorinhibit

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