2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116792
    Phenoxyacetone
    		Inhibitor 99.38%
    Phenoxyacetone is a acetylcholinesterase (AChE) inhibitor.
    Phenoxyacetone
  • HY-B1093
    Fenchlorphos
    		Inhibitor 99.87%
    Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.
    Fenchlorphos
  • HY-10399A
    Ladostigil hydrochloride
    		Inhibitor 99.94%
    Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease. Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hydrochloride
  • HY-N6895
    Violanthin
    		Inhibitor
    Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM.
    Violanthin
  • HY-P5189A
    His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA
    		99.31%
    His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels.
    His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA
  • HY-21629
    N-Boc-4-piperidinemethanol
    		Inhibitor 99.72%
    N-Boc-4-piperidinemethanol (compound 4) is an acetylcholinesterase (AChE) inhibitor. N-Boc-4-piperidinemethanol can used ti study Alzheimer’s Disease.
    N-Boc-4-piperidinemethanol
  • HY-B2155
    Acotiamide monohydrochloride trihydrate
    		Inhibitor 99.49%
    Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
    Acotiamide monohydrochloride trihydrate
  • HY-W016188
    1-Naphthyl acetate
    		99.79%
    1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning.
    1-Naphthyl acetate
  • HY-N2157
    Pteryxin
    		Inhibitor 99.96%
    Pteryxin, a coumarin in Peucedanum japonicum Thunb leaves, exerts antiobesity activity. Pteryxin is a potent butyrylcholinesterase (BChE) inhibitor, with an IC50 of 12.96 μg/ml.
    Pteryxin
  • HY-136838
    (R)-Donepezil
    		Inhibitor 99.91%
    (R)-Donepezil is a R-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor.
    (R)-Donepezil
  • HY-100919
    Ambenonium chloride
    		Inhibitor
    Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE).
    Ambenonium chloride
  • HY-B1337S3
    Choline-d13 chloride
    		99.90%
    Choline-d13 (chloride) is the deuterium labeled Choline chloride. Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
    Choline-d<sub>13</sub> chloride
  • HY-14566A
    (S)-Donepezil
    		Inhibitor
    (S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor.
    (S)-Donepezil
  • HY-106456
    Depramine
    		Inhibitor
    Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase，Mg2+-ATPase，and Na+/K+ ATPase activity.
    Depramine
  • HY-19651
    Zanapezil free base
    		Inhibitor 99.23%
    Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).
    Zanapezil free base
  • HY-B0207AS
    Pyridostigmine-d6 bromide
    		Inhibitor 99.17%
    Pyridostigmine-d6 (bromide) is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.
    Pyridostigmine-d<sub>6</sub> bromide
  • HY-N2211
    Picfeltarraenin IB
    		Inhibitor 98.53%
    Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.
    Picfeltarraenin IB
  • HY-N3468
    Isomerazin
    		Inhibitor 99.39%
    Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition.
    Isomerazin
  • HY-17587S
    4-Methylbenzylidene camphor-d4
    4-Methylbenzylidene camphor-d4 is the deuterium labeled 4-Methylbenzylidene camphor[1].
    4-Methylbenzylidene camphor-d<sub>4</sub>
  • HY-W011246
    Velnacrine maleate
    		Inhibitor ≥98.0%
    Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
    Velnacrine maleate
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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