Cholinesterase (ChE)

Cholinesterase (ChE) Related Products (434):

By Effects:	Inhibitors (362) Controls (4) Agonists (4) Antagonists (6) Activators (11) Modulators (3)

Cat. No.	Product Name	Effect	Purity

HY-Y0320

Dimethyl sulfoxide, meets analytical specification of Ch.P.	Inhibitor	99.99%
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties. MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.

HY-Y0320C

Dimethyl sulfoxide	Inhibitor	99.98%
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Low endotoxin, can be used in various biochemical experiments such as drug dissolution.

HY-P2860

Acetylcholinesterase, Fly head
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses used in biochemical research. Acetylcholinesterase, Fly head catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase, Fly head's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.

HY-B2152

Hemicholinium 3	Inhibitor	99.71%
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a K_i value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh). Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [³H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively.

HY-N0793

Protopine	Inhibitor	99.64%
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity.

HY-W009431

AChE-IN-84	Inhibitor
AChE-IN-84 (compound 21) is an AChE inhibitor.

HY-W022759

9-Acridinecarboxylic acid	Inhibitor
9-Acridinecarboxylic acid is a precursor of a cholinesterase inhibitor, and its derivatives have nanomolar inhibitory potency against AChE and BChE.

HY-131922

Iso-OMPA	Inhibitor	99.90%
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of the irreversible butyrylcholinesterase (BuChE). Iso-OMPA enhances soman toxicity in rats associated with the inhibition of plasma carboxylesterase (CarbE).

HY-B1337S1

Choline-d₉ chloride		99.77%
Choline-d₉ (chloride) is the deuterium labeled Choline chloride. Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.

HY-136610

Chlorpyrifos-oxon	Inhibitor	99.39%
Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.

HY-B0423

Neostigmine Bromide	Inhibitor	99.91%
Neostigmine (Eustigmin) Bromide is an orally active and reversible cholinesterase inhibitor that acts on myasthenia gravis to prolong and intensify the muscarinic and nicotinic effects of acetylcholine. Neostigmine Bromide can be used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

HY-B1206

Neostigmine methyl sulfate	Inhibitor	99.50%
Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.

HY-N6608

Physostigmine	Inhibitor	99.92%
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

HY-107825

Flavonol	Inhibitor	99.92%
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases.

HY-B1337S

Choline-d₄ chloride		≥99.0%
Choline-d₄ (chloride) is the deuterium labeled Choline chloride. Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.

HY-B1337S4

Choline Chloride-¹³C₃		99.69%
Choline Chloride-¹³C₃ is the ¹³C-labeled Choline (chloride). Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.

HY-B1946

Dimethoate	Inhibitor	99.91%
Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces reactive oxygen species (ROS). Dimethoate induces DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice.

HY-N8376

Fustin	Inhibitor	98.07%
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research.

HY-N8290

Lactupicrin	Inhibitor	99.97%
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone.

HY-B1626A

Demecarium Bromide	Inhibitor
Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (K_iapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent.

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