2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)
  5. Cholinesterase (ChE) Modulator

Cholinesterase (ChE) Modulator

Cholinesterase (ChE) Isoform Comparison

Cholinesterase (ChE) Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-W014700
    Glycyl-L-glutamic acid
    		Modulator
    Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration.
  • HY-162657
    AChE-IN-74
    		Modulator
    AChE-IN-74 (Compound 10) is a modulator for cholinesterase. AChE-IN-74 inhibits the proliferation of liver cancer cell Hep3B and SkHep1 with IC50 of 3.6 and 19.9 μM. AChE-IN-74 exhibits a low embryonic toxicity in zebrafish models (10-15 μM).
  • HY-12153
    JNJ-1930942
    		Modulator
    JNJ-1930942 is a selective and blood-brain barrier (BBB) penetrant α(7) nAChR positive allosteric modulator.JNJ-1930942 enhances the Choline (HY-B0282)-evoked rise in intracellular Ca2+ levels and neurotransmission at hippocampal dentate gyrus synapses. JNJ-1930942 reverses the naturally occurring sensory gating deficit in DBA/2 mice.
  • HY-119772
    VU0366369
    		Modulator
    VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases.