1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Cholinesterase (ChE) Inhibitors

Cholinesterase (ChE) Inhibitors

AChE

BChE

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Cholinesterase (ChE) Inhibitors, Agonists, Antagonists, Activators & Chemicals
Product Name AChE BChE Purity
Donepezil Hydrochloride
AChE
  99.92%
Donepezil
AChE
  99.91%
TMPyP4 tosylate
AChE
  ≥98.0%
Galanthamine
AChE
  99.96%
Rivastigmine
AChE
BChE
99.93%
α-NETA
AChE
  ≥98.0%
Garcinol
AChE
BChE
≥99.0%
Imperatorin
AChE
BChE
98.72%
Physostigmine salicylate
AChE
  99.37%
Scopoletin
AChE
  99.89%
(-)-Huperzine A
AChE
  99.74%
Linarin
AChE
  98.00%
Pyridostigmine bromide
AChE
  99.93%
Tacrine
AChE, IC50: 109 nM
  99.91%
Epiberberine chloride
AChE
BChE
99.02%
Buntanetap
AChE
  99.71%
Isoimperatorin
AChE
  99.61%
Sinapine
AChE
  99.96%
Rivastigmine tartrate
AChE
  99.71%
Timosaponin AIII
AChE
  99.73%
Tacrine hydrochloride
AChE
BChE
99.95%
Chlorpyrifos
AChE
  99.88%
Corynoline
AChE
  99.12%
Ethopropazine hydrochloride
AChE
BChE
99.66%
Jatrorrhizine chloride
AChE
  99.88%
Sinapine thiocyanate
AChE
  99.74%
Corydaline
AChE
  99.70%
Tacrine hydrochloride (hydrate)
AChE
BChE
99.98%
Profenofos
AChE
 
Rhodiosin
AChE
  99.36%
Galanthamine hydrobromide
AChE
  99.93%
Itopride hydrochloride
AChE
  99.85%
Nodakenin
AChE
  98.76%
Cyanidin-3-O-galactoside chloride
AChE
  99.20%
N-p-trans-Coumaroyltyramine
AChE
  98.78%
Pralidoxime chloride
AChE
  99.73%
Acephate
AChE
  ≥98.0%
Coumaran
AChE
  99.54%
Tenuifolin
AChE
  99.24%
(-)-Carvone
eel AChE, Ki: 2.19 mM
  99.55%
RPR121056
AChE
  99.59%
Rhodionin
AChE
  98.78%
Phenserine
AChE
  99.55%
Physostigmine hemisulfate
AChE
  ≥99.0%
Isoeugenol acetate
AChE
  99.92%
Pralidoxime iodide
AChE
  ≥98.0%
Benactyzine hydrochloride  
BChE, Ki: 0.01 mM
99.02%
β-NETA
AChE
  ≥98.0%
PCS1055 dihydrochloride
AChE
  98.88%
Mca-YVADAP-Lys(Dnp)-OH TFA
AChE
  98.85%
Picfeltarraenin IA
AChE
  99.83%
Pirimiphos-methyl
AChE
  98.00%
(±)-Huperzine A
AChE
  98.73%
Drofenine hydrochloride  
BChE
98.10%
Penconazole
AChE
  98.91%
Fenchlorphos
AChE
  99.87%
Ladostigil hydrochloride
AChE, IC50: 31.8 μM
  99.94%
Violanthin
AChE
 
Acotiamide monohydrochloride trihydrate
AChE
  99.49%
Pteryxin  
BChE
99.96%
BChE-IN-17
eel AChE, IC50: 686.4 μM
eqBCHE, IC50: 10.5 nM
hBCHE, IC50: 32.5 nM
99.07%
Zanapezil free base
AChE
  99.23%
Picfeltarraenin IB
AChE
  98.53%
Polygalacic acid
AChE
  98.92%
PE154
AChE, IC50: 280 pM
BChE, IC50: 16 nM
99.01%
Phenthoate
AChE
  98.71%
Zanapezil fumarate
AChE
  99.63%
Ebeiedinone
AChE
BChE
99.51%
P11149
AChE
  99.23%
Galanthamine N-Oxide
AChE
BChE
99.90%
Pitofenone hydrochloride
AChE
  99.88%
Epiberberine
AChE
BChE
98.46%
Pirimicarb
AChE
  99.50%
PCS1055
hAChE, IC50: 120 nM
  98.02%
Y13g dihydrochloride
AChE
  99.89%
Swertianolin
AChE
  99.54%
Zanapezil
AChE
  99.63%
Dihydrowithaferin A
AChE
  ≥99.0%
Sophoflavescenol
AChE
BChE
98.15%
(±)-Marmesin
AChE
 
ASS234
AChE, IC50: 350 nM
BChE, IC50: 460 nM
99.6%
Territrem B
AChE
 
Isorosmanol
AChE
  98.08%
AChE/BChE-IN-10
AChE, IC50: 0.176 μM
BChE, IC50: 0.47 μM
99.67%
Manghaslin
AChE
  ≥98.0%
Z32439948  
BChE, IC50: 1.4 μM ([1])
HDAC6-IN-5
AChE, IC50: 0.72 μM
 
AChE/BChE-IN-1
AChE
BChE
ZLMT-12
AChE, IC50: 19.023 μM
BChE, IC50: 2.768 μM
AChE-IN-72
AChE, IC50: 0.59 μM
BChE, IC50: 5.02 μM
hAChE-IN-6
hAChE, IC50: 0.16 μM
hBCHE, IC50: 0.69 μM
SB-1436
EeAChE, IC50: 0.176 μM
EeAChE, Ki: 0.046 μM
eqBCHE, IC50: 0.37 μM
eqBCHE, Ki: 0.115 μM
hAChE-IN-9
hAChE, IC50: 0.05 μM
hBCHE, IC50: 2.85 μM
AChE/BChE-IN-18
AChE, IC50: 0.315 μM
 
BChE-IN-6  
BChE, Ki: 0.182 μM
Methylene Violet 3RAX
AChE, Ki: 1.58 μM
BChE, Ki: 0.51 μM
AChE-IN-60
AChE, IC50: 27 nM
BChE, IC50: 43 nM
Azamethiphos
AChE
 
AChE-IN-44
AChE
 
K203
AChE
 
AChE-IN-28
AChE, IC50: 0.2 nM
 
ChEs/MAOs-IN-2
AChE, IC50: 0.30 μM
BChE, IC50: 0.40 μM
Isogarcinol
AChE, IC50: 1.13 ± 0.0 μM
BChE, IC50: 8.30 ± 0.0 μM
BChE-IN-36
EeAChE, IC50: 72.1 nM
eqBCHE, IC50: 4.2 nM
Stemoninine
hAChE, IC50: 5.52 μM
 
AChE/BuChE-IN-5
AChE, IC50: 46.9 nM
RatBuChE, IC50: 3.5 nM
Kuwanon U
AChE, IC50: 19.69 μM
AChE, IC50: 6.48 μM
BChE, Ki: 10.11 μM
BChE, Ki: 9.59 μM
AChE/BChE/MAO-B-IN-3
hAChE, IC50: 0.0473 μM
hBCHE, IC50: 0.0782 μM
hBChE-IN-2  
hBCHE, IC50: 0.67 μM
Y13g
AChE
 
AChE-IN-35
AChE, IC50: 5.88 μM
 
Z164597606  
eqBCHE, IC50: 1.3 μM
hBCHE, IC50: 1.7 μM
Pralidoxime
AChE
 
Xanthohumol I
AChE
BChE
SBN-284
EeAChE, IC50: 0.37 μM
hAChE, IC50: 0.31 μM
eqBCHE, IC50: 0.29 μM
AChE/BACE1/GSK3β-IN-1
AChE, IC50: 1 μM
 
AChE/MAO-IN-1
hAChE, IC50: 0.0248 μM
 
Blestrin D  
BChE, IC50: 8.1 μM
AChE-IN-22
AChE
 
eeAChE-IN-2
AChE
 
AChE/BChE-IN-16
hAChE, IC50: 30 nM
hBCHE, IC50: 48 nM
hAChE/Aβ1-42-IN-1
AChE
 
Protriptyline
AChE, IC50: 0.06 mM
 
BChE-IN-19  
BChE, IC50: 0.04 μM
MAO-B-IN-7
hAChE, IC50: 41 nM
 
AChE/Aβ-IN-3
AChE, IC50: 1.29 μM
 
BuChE-IN-7  
hBCHE, IC50: 40 nM
eqBCHE, IC50: 80 nM
K027
AChE
BChE
AChE/BChE/MAO-B-IN-2
AChE, IC50: 83.9 nM
BChE, IC50: 31.2 nM
Bis-(-)-8-demethylmaritidine
AChE
 
Carbonic anhydrase/AChE-IN-1
AChE, Ki: 5.07 nM
 
hAChE-IN-2
hAChE, IC50: 0.71 μM
 
BChE-IN-33  
BChE, IC50: 14.78 nM
BChE-IN-32  
hBCHE, IC50: 0.109 μM
AChE-IN-75
AChE
 
AChE/MAO-B-IN-3
hAChE, IC50: 0.0257 μM
 
Picfeltarraegenin X
AChE
 
MR33317
AChE, IC50: 41 nM
 
BChE-IN-16  
hBCHE, IC50: 3.8 nM
H3R antagonist 4
hAChE, IC50: 9.73 μM
EeAChE, IC50: 7.04 μM
eqBCHE, IC50: 13.40 ~ 88 μM
Multitarget AD inhibitor-2
AChE, IC50: 0.14 μM
BChE, IC50: 11.6 μM
hAChE/hBACE-1-IN-1
hAChE, IC50: 0.076 μM
hBACE-1, IC50: 0.23 μM
hBCHE, IC50: 1.204 μM
K1833
hAChE, IC50: 58 μM
hBCHE, IC50: 0.57 μM
AChE/CA I-IN-1
AChE, Ki: 1.85 μM
 
Desoxypeganine
AChE, IC50: 17 μM
BChE, IC50: 2 μM
BChE-IN-35  
BChE
AChE/BChE-IN-12
EeAChE, IC50: 2.57 ± 0.3 μM
eqBCHE, IC50: 3.26 ± 0.1 μM
Bisnorcymserine  
BChE, IC50: 0.228 nM
BChE-IN-12  
BChE, IC50: 2.3 μM
hAChE/hBACE-1-IN-4
hAChE, IC50: 0.283 μM
hBCHE, IC50: 0.231 μM
AChE-IN-19
AChE
 
AChE-IN-77
AChE, IC50: 29.46 μM
 
Lycodoline  
BChE, IC50: 667 μM
AChE-IN-8
AChE
 
AChE-IN-46
AChE
 
Dual AChE-MAO B-IN-3
EeAChE, IC50: 0.58 ± 0.0 μM
 
BuChE-IN-12  
BChE, IC50: 0.52 nM
Broussonin A  
BChE, IC50: 4.16 μM
Memoquin
hAChE, IC50: 1.55 nM
 
S21-1011  
eqBCHE, IC50: 0.059 μM
hBCHE, IC50: 0.162 μM
AChE-IN-17
AChE
 
Isoprocarb
AChE
 
CEase-IN-1
AChE, IC50: 45.9 μM
 
AChE-IN-5
AChE
 
ChE/Aβ1-42-IN-1
AChE
 
AChE/BChE-IN-11
AChE, IC50: 70 μM
BChE, IC50: 71 μM
AChE/BChE-IN-17
AChE, IC50: 125.06 ± 2 nM
BChE, IC50: 119.68 ± 2 nM
AChE-IN-69
AChE, IC50: 1.67 μM
 
Kokusaginine
AChE, IC50: 28.2 μM
 
BChE-IN-31
AChE, IC50: 5.9 μM
BChE, IC50: 65 nM
AChE/BChE-IN-20
AChE, IC50: 34.81 μM
BChE, IC50: 20.66 μM
NDs-IN-1
hAChE
hBCHE
Fmoc-L-Val-OH-13C5,15N
AChE
  ≥98%
BChE-IN-5
AChE
BChE
Flucopride
AChE, IC50: 24 nM
 
tau/Aβ40 aggregation-IN-1
hAChE, IC50: 16.10 μM
equine serum BChE, IC50: 0.96 μM
AChE/BChE-IN-6
hAChE, IC50: 2.248 μM
hBCHE, IC50: 0.809 μM
AChE-IN-24
AChE
 
AChE-IN-51
AChE, IC50: 84 nM
BChE, IC50: 97 nM
Artanin
AChE, IC50: 51 μM
 
AChE/BuChE/MAO-B-IN-1
hAChE, IC50: 4.8 μM
hBCHE, IC50: 13.7 μM
CL-13  
BChE, IC50: 1.15 μM
Monarsen
AChE
 
AChE/BuChE-IN-3
AChE, IC50: 0.65 μM
BChE, IC50: 5.77 μM
AChE/BChE-IN-24
AChE, IC50: 16.38 μM
BChE, IC50: 10.44 μM
hAChE-IN-8
hAChE, IC50: 0.486 μM
hBCHE, IC50: 0.542 μM
AChE-IN-64
AChE, IC50: 36.9 μM
 
eeAChE-IN-3
EeAChE, IC50: 0.54 μM
RatAChE, IC50: 0.49 μM
RatBuChE, IC50: 8.54 μM
BChE-IN-26
AChE, Ki: 35 μM
BChE, Ki: 1.6 μM
α-Glucosidase-IN-68
AChE, IC50: 0.774 μM
BChE, IC50: 0.793 μM
TRV-7019  
BChE
99.64%
AChE-IN-21
EeAChE, IC50: 2.66 nM
RatBuChE, IC50: 19.10 μM
AChE-IN-67
AChE, IC50: 0.033±0.00 μM
BChE, IC50: >100 μM
Suillin
AChE, IC50: 31.5 μM
 
MAO-A/B-IN-3
AChE, IC50: 1370 nM
 
AChE-IN-52
AChE
 
BChE-IN-15
hAChE, IC50: 558.6 nM
hBCHE, IC50: 1.76 nM
AChE-IN-59
AChE, IC50: 0.05 μM
BChE, IC50: 4.68 μM
Desoxypeganine hydrochloride
AChE, IC50: 17 μM
BChE, IC50: 2 μM
AChE/BChE-IN-3 hydrochloride
AChE
BChE
MR2938
AChE, IC50: 5.04 ± 0.7 μM
BChE, IC50: >20 μM
BChE-IN-10  
BChE, IC50: 6.4 μM
AChE/MAO-B-IN-4
AChE
 
SD-6
hAChE, IC50: 0.907 μM
hBCHE, IC50: 1.579 μM
hCAI/II-IN-8
AChE, IC50: 46.27 ±0.7 nM
BChE, IC50: 43.38 ± 0. nM
Itopride
AChE
 
S16–1029  
eqBCHE, IC50: 11.35 nM
hBCHE, IC50: 48.1 nM
BChE-IN-11  
BChE, IC50: 2.1 ± 0.3 μM
Isoprocarb-d3
AChE
 
AChE/BuChE/MAO-B-IN-2
AChE, IC50: 5.3 μM
BChE, IC50: 12.4 μM
MHP 133
AChE, Ki: 69 μM
 
hBChE-IN-3
AChE, IC50: 7.4 nM
BChE, IC50: 1.9 nM
AChE/MAO-IN-2
AChE, IC50: 0.0224 μM
 
hAChE-IN-3
AChE, IC50: 0.44 μM
BChE, IC50: 0.08 μM
AChE/PDE4-IN-1
AChE, IC50: 0.28 μM
 
α-Amylase/α-Glucosidase-IN-7
AChE, IC50: 9.25 μM
BChE, IC50: 10.06 μM
hAChE-IN-1
hAChE, IC50: 1.09 μM
 
AChE-IN-63
hAChE, IC50: 0.103 μM
hBCHE, IC50: 10 μM
BChE-IN-34  
eqBCHE, IC50: 25 nM
AChE-IN-4
AChE, IC50: 24.1 μM
 
BChE-IN-22  
eqBCHE, IC50: 0.53 μM
BuChE-IN-11  
hBCHE, IC50: 0.44 μM
AChE-IN-20
AChE, IC50: 397.32 nM
AChE, Ki: 335.76 nM
 
BChE-IN-28
AChE, IC50: 3691 nM
BChE, IC50: 8 nM
BChE, Ki: 12.16 nM
AChE-IN-34
AChE, IC50: 3.98 μM
AChE, Ki: 0.044 μM
 
Dual AChE-MAO B-IN-4
AChE, IC50: 261 nM
 
Manumycin B
AChE, IC50: 15 mM
 
(Rac)-Sclerone
AChE, IC50: 192.65 ± 1 μg/mL
 
BChE/MAO-B-IN-1  
BChE, IC50: 375 nM
AChE-IN-68
hAChE, IC50: 0.040 ± 0. μM
hBCHE, IC50: >1000 μM
eeAChE-IN-1
AChE
 
AChE/BChE-IN-19
AChE, IC50: 21.45 nM
BChE, IC50: 18.42 nM
AChE-IN-55
EeAChE, IC50: 4.8 μM
 
Methyl ganoderate A acetonide
AChE
 
Isograndifoliol
AChE, IC50: 342.9 μM
BChE, IC50: 0.9 μM
hBChE-IN-1
EeAChE, IC50: 0.18 μM
hAChE, IC50: 7.84 ± 0.8 μM
hBCHE, IC50: 0.0070 ± 0 μM
equine serum BChE, IC50: 0.088 μM
AChE/Aβ-IN-4
AChE, IC50: 1.72 ± 0.1 μM
 
AChE-IN-47
AChE
 
AChE-IN-11
AChE
 
AChE-IN-10
AChE
 
Velnacrine
AChE, IC50: 3.27 μM
 
Anatoxin-a
AChE
 
AChE-IN-56
AChE
 
hAChE/hBACE-1-IN-2
hAChE, IC50: 0.113 μM
hBACE-1, IC50: 0.38 μM
hBCHE, IC50: 1.48 μM
BChE-IN-29
AChE, IC50: 0.74 μM
BChE, IC50: 0.075 μM
Benactyzine  
BChE, Ki: 0.01 mM
Lucidadiol
AChE, IC50: 31.03 μM
BChE, IC50: 156.27 μM
WAY-361789
AChE
 
AL284
AChE
 
T14-A24
AChE, Ki: 22 nM
 
7-Methoxytacrine
hAChE, IC50: 10.5 μM
hBCHE, IC50: 21 μM
TAE-1
AChE