Angiotensin Receptor Antagonist

Angiotensin Receptor Antagonists (107):

Cat. No.	Product Name	Effect	Purity

HY-19202

rac-Olodanrigan	Antagonist
rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT₂ receptor antagonist with IC₅₀s of 75.2 nM and 2918 nM for AT₂R and AT₁R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.

HY-117743R

Eprosartan (Standard)	Antagonist
Eprosartan (Standard) is the analytical standard of Eprosartan. This product is intended for research and analytical applications. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-105010

FK-739 free base	Antagonist
FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension.

HY-117858

CL-329167	Antagonist
CL-329167 (compound 12) is an orally active and competitive angiotensin II receptor antagonist (IC₅₀=6 nM). CL-329167 can be used in the research of hypertension.

HY-W741441

Tetrahydro Aldosterone	Antagonist
Tetrahydro Aldosterone is a steroid which can inhibit adrenal angiotensin II receptors with an IC₅₀ of 10 μM.

HY-12765R

Losartan Carboxylic Acid (Standard)	Antagonist
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].

HY-14914R

Azilsartan (Standard)	Antagonist
Azilsartan (Standard) is the analytical standard of Azilsartan. This product is intended for research and analytical applications. Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research.

HY-19156A

ZD-6888 hydrochloride	Antagonist
ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function.

HY-W414915R

Valsartan methyl ester (Standard)	Antagonist
Valsartan methyl ester (Standard) is the analytical standard of Valsartan methyl ester. This product is intended for research and analytical applications. Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC50 of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC50 of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.).

HY-17512R

Losartan (Standard)	Antagonist
Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-121767

PD 123177	Antagonist
PD 123177 is a nonpeptide antagonist specific for angiotensin II (AII) subtype AT2 receptor in mammalian systems.

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Antagonist
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.

HY-117627

L 158338	Antagonist
L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion.

HY-101574

Pratosartan	Antagonist
Pratosartan is a selective angiotensin II receptor antagonist.

HY-19214

Elisartan	Antagonist
Elisartan is an orally active non-peptide pro-agent of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities.

HY-101706

CGP48369	Antagonist
CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.

HY-19191

L-159282	Antagonist
L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.

HY-101618

L162389	Antagonist
L162389 is a potent antagonist of angiotensin AT1 receptor with K_i of 28 nM.

HY-101823A

A-81282	Antagonist
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a p_A2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a p_KI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats.

HY-106890

E4177	Antagonist
E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases.

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