2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (49):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12176
    Aliskiren
    		Inhibitor 99.24%
    Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
    Aliskiren
  • HY-12177
    Aliskiren hemifumarate
    		Inhibitor 99.80%
    Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
    Aliskiren hemifumarate
  • HY-151111
    SPH3127
    		Inhibitor 98.26%
    SPH3127 (DRI 18) is a novel, highly potent, and orally active direct renin inhibitor (recombinant human-renin IC50=0.4 nM, human plasma renin activity IC50=0.45 nM). SPH3127 shows antihypertensive effect and can be used in essential hypertension research.
    SPH3127
  • HY-N2115
    Araloside A
    		Inhibitor 98.31%
    Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.
    Araloside A
  • HY-76652
    VTP-27999 Hydrochloride
    		Inhibitor 98.18%
    VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
    VTP-27999 Hydrochloride
  • HY-12174
    Zankiren
    		Inhibitor
    Zankiren (A-72517) is an orally active inhibitor for renin. Zankiren exhibits renal vasodilator effect, through reduction of angiotensin II formation without affecting other vasodilator mechanisms.
    Zankiren
  • HY-P2075
    EMD 55068
    		Antagonist
    EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate.
    EMD 55068
  • HY-P2024
    CP-85339
    		Inhibitor
    CP-85339 is a tetrapeptide renin inhibitor.
    CP-85339
  • HY-50769
    VTP-27999 TFA
    		Inhibitor
    VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
    VTP-27999 TFA
  • HY-N9528
    Lyciumin A
    		Inhibitor ≥99.0%
    Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension.
    Lyciumin A
  • HY-12176B
    Aliskiren fumarate
    		Inhibitor
    Aliskiren fumarate is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
    Aliskiren fumarate
  • HY-12176A
    Aliskiren hydrochloride
    		Inhibitor
    Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia-.
    Aliskiren hydrochloride
  • HY-P3878
    Renin substrate 1
    Renin substrate 1 is a renin substrate with high affinity to the enzyme.
    Renin substrate 1
  • HY-B1562C
    Bopindolol fumarate
    		Inhibitor
    Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol fumarate is a proagent of Pindolol (HY-B0982). Bopindolol fumarate can be used for essential and renovascular hypertension research.
    Bopindolol fumarate
  • HY-120673
    SQ 32970
    		Inhibitor
    SQ 32970 is a tripeptidic renin inhibitor. SQ 32970 potently inhibits endothia protease.
    SQ 32970
  • HY-B1562
    Bopindolol
    		Inhibitor
    Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol
  • HY-50768
    VTP-27999
    		Inhibitor
    VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
    VTP-27999
  • HY-P2147
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome
    		Inhibitor
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome is a specific renin inhibitor.
    Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome
  • HY-B1562B
    Bopindolol (malonate)
    		Inhibitor
    Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.
    Bopindolol (malonate)
  • HY-118033
    SQ 30774
    		Inhibitor
    SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo.
    SQ 30774