2. GPCR/G Protein Protein Tyrosine Kinase/RTK
  3. Angiotensin Receptor PDGFR
  4. E4177

E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases.

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E4177 Chemical Structure

E4177 Chemical Structure

CAS No. : 135070-05-2

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E4177 Related Antibodies

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Description

E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases[1].

Molecular Weight

383.44

Formula

C24H21N3O2
CAS No.
SMILES

O=C(C1=C(C2=CC=C(CN3C4=NC=CC(C)=C4N=C3C5CC5)C=C2)C=CC=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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E4177 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E4177135070-05-257G709E 4177E-4177Angiotensin ReceptorPDGFRPlatelet-derived growth factor receptorOrally activeantagonistvascular smooth muscle cellsvascular diseasePDGFInhibitorinhibitorinhibit

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