2. GPCR/G Protein
  3. Angiotensin Receptor
  4. rac-Olodanrigan

rac-Olodanrigan  (Synonyms: rac-EMA401; rac-PD-126055; EMA400)

Cat. No.: HY-19202
Handling Instructions

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rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.

For research use only. We do not sell to patients.

rac-Olodanrigan Chemical Structure

rac-Olodanrigan Chemical Structure

CAS No. : 152362-51-1

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rac-Olodanrigan Related Antibodies

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Description

rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve[1].

IC50 & Target[1]

AT2 Receptor

75.2 nM (IC50)

AT1 Receptor

2918 nM (IC50)

Molecular Weight

507.58

Formula

C32H29NO5
CAS No.
SMILES

O=C(C1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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rac-Olodanrigan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

rac-Olodanrigan152362-51-1rac-EMA401 rac-PD-126055 EMA400EMA400EMA 400EMA-400Angiotensin ReceptorS-enantiomerEMA402AT2AT2RAT1Rallodyniachronic constriction injuryCCIInhibitorinhibitorinhibit

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