rac-Olodanrigan (Synonyms: rac-EMA401; rac-PD-126055; EMA400)

Cat. No.: HY-19202: FAQs
Data Sheet Handling Instructions

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rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT₂ receptor antagonist with IC₅₀s of 75.2 nM and 2918 nM for AT₂R and AT₁R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve.

For research use only. We do not sell to patients.

rac-Olodanrigan Chemical Structure

CAS No. : 152362-51-1

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Other Forms of rac-Olodanrigan:

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Description

IC₅₀ & Target^[1]

AT2 Receptor

75.2 nM (IC₅₀)

AT1 Receptor

2918 nM (IC₅₀)

Molecular Weight

507.58

Formula

C₃₂H₂₉NO₅

CAS No.

152362-51-1

SMILES

O=C(C1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maree T Smith. Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain. 2022 Nov 1;163(Suppl 1):S15-S28. [Content Brief]

rac-Olodanrigan Related Classifications

Neurological Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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