PABPC3 - poly(A) binding protein cytoplasmic 3 Gene

Homo sapiens

Also known as PABP3; tPABP; PABPL3

Gene ID: 5042 | Gene type: protein coding

About PABPC3

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:25,096,136-25,099,254 (from NCBI)

This gene has 1 transcript (splice variant), 108 orthologues and 24 paralogues.

Summary

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

PABPC3 Products(1)

mRNA	Protein	Name
NM_030979.3	NP_112241.2	polyadenylate-binding protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables poly(A) binding	IDA IDA: Inferred from direct assay	11328870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC3 Protein Structure

RRM_1

PABP

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein 3

PABP-3

PABPC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PABPC3	Q9H361	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PABPC3	Q9H361	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PABPC3	Q9H361	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PABPC3	Q9H361	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PABPC3	Q9H361	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PABPC3	Q9H361	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes

Cronkhite-Canada Syndrome	Gastric Cronkhite Canada Polyposis
Cronkhite-Canada Disease	Polyposis Skin Pigmentation Alopecia Fingernail Changes
Gastrointestinal Polyposis-Ectodermal Changes Syndrome	Gastrointestinal Polyposis-Skin Pigmentation-Alopecia-Fingernail Changes Syndrome
Polyposis, Gastrointestinal, With Ectodermal Changes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09949	PABPC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PABPC3	RGD	RGD:1311201
Macaca mulatta	PABPC3	VGNC	VGNC:106280
Mus musculus	PABPC3	MGD	MGI:1349722

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