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nlrp3-in-39

" within the MedChemExpress (MCE) catalog. Here are the results you might be looking for.

By Targets:	Cholinesterase (ChE) (1) IKK (1) NF-κB (1) NOD-like Receptor (NLR) (13) Reactive Oxygen Species (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (12) Neurological Disease (3)

Targets Recommended: AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*NLRP3-IN-37*	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-37 (Compound 23) is a NLRP3 inhibitor (EC₅₀: 5 nM). NLRP3-IN-37 can be used for NLRP3 related research, such as gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiophathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury .

*NLRP3-IN-35*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-35 (compound 11) is an NLRP3 inhibitor (IC₅₀ < 1 μM) .

*NLRP3-IN-38*	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC₅₀ of 23 nM .

*NLRP3-IN-34*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC₅₀ is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis .

*NLRP3-IN-36*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-36 (Compound 111) is an NLRP3 inhibitor (IC₅₀ <1 μM) .

*NLRP3-IN-29*	NOD-like Receptor (NLR)	Neurological Disease
NLRP3-IN-29(Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3). NLRP3-IN-29 has the potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. NLRP3-IN-29 can be used for research on Alzheimer's disease .

*NLRP3-IN-30*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-30 (Compound A14) is a potent NLRP3 inhibitor, with an IC₅₀ of 44.43 nM. NLRP3-IN-30 has highly oral bioavailability (F is 83.09% in mice) .

*NLRP3-IN-31*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-31 (Comp 14) is a NLRP3 inhibitor, with an IC₅₀ of 0.3-0.5 μM .

*NLRP3-IN-32*	NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK	Inflammation/Immunology
NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling .

*NLRP3-IN-33*	Reactive Oxygen Species Cholinesterase (ChE)	Cancer
NLRP3-IN-33 (Compound 12o) is a blood-brain barrier permeable inhibitor of AChE and BChE, with IC₅₀ values of 1.02 μM and 7.03 μM against hAChE and hBChE respectively. NLRP3-IN-33 possesses antioxidant, anti-inflammatory, and metal chelating activities, making it a potential candidate for research in Alzheimer's disease (AD) .

*NLRP3-IN-49*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC₅₀=0.26 μM in THP-1 cells, IC₅₀=0.21 μM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to NLRP3 protein (K_d=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease .

*NLRP3-IN-9*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout .

JT001 nlrp3-in-19	NOD-like Receptor (NLR)	Inflammation/Immunology
JT001 (NLRP3-IN-19) is a potent, specific and orally active inhibitor of NLRP3. JT001 can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 can be used for the research of nonalcoholic steatohepatitis and liver fibrosis .

JT001 sodium nlrp3-in-19 sodium	NOD-like Receptor (NLR)	Inflammation/Immunology
JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis .

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