2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-38

NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM.

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NLRP3-IN-38 Chemical Structure

NLRP3-IN-38 Chemical Structure

CAS No. : 3033054-46-2

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NLRP3-IN-38 Related Antibodies

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Description

NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM[1].

IC50 & Target

NLRP3 inflammasome

23 nM (EC50)

Molecular Weight

418.41

Formula

C21H21F3N4O2
CAS No.
SMILES

C[C@H]1CN(C[C@H]([C@@H]1O)C)C2=C3C=NC=CC3=C(N=N2)C4=CC=C(C=C4O)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-383033054-46-2NOD-like Receptor (NLR)Alzheimer's DiseaseParkinson's DiseaseNASH fibrosisheart failureinflammatory bowel diseasegoutInhibitorinhibitorinhibit

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