2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-49

NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 μM in THP-1 cells, IC50=0.21 μM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease.

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NLRP3-IN-49 Chemical Structure

NLRP3-IN-49 Chemical Structure

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NLRP3-IN-49 Related Antibodies

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Description

NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 μM in THP-1 cells, IC50=0.21 μM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease[1].

Molecular Weight

491.40

Formula

C22H23BrN2O4S
SMILES

BrC1=CC=C(C=C1)/C=C(C(NCCC2=C(C=CC=C2)OC)=O)\CS(CCC#N)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NLRP3-IN-49 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-49NOD-like Receptor (NLR)SpecificityinhibitorTHP-1 cellsmouse bone marrow macrophagesinflammasomeanti-inflammatoryInhibitorinhibit

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