2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-9

NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout.

For research use only. We do not sell to patients.

NLRP3-IN-9 Chemical Structure

NLRP3-IN-9 Chemical Structure

CAS No. : 2768759-64-2

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NLRP3-IN-9 Related Antibodies

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Description

NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout[1].

IC50 & Target[1]

NLRP3

 

In Vitro

NLRP3-IN-9 (compound 4b) (0.01-3 µM) inhibits IL-1β release in a dose-dependent manner in ATP (5 mM) and LPS (1 µg/mL)-induced macrophages[1].
NLRP3-IN-9 (1 µM; 15 min) inhibits NLRP3 inflammasome oligomerization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NLRP3-IN-9 Related Antibodies

Western Blot Analysis[1]

Cell Line: Macrophages
Concentration: 1 µM
Incubation Time: 15 min
Result: Inhibited teh expression of IL-1β P17, Casp-1 p10 peotein levelwith the ATP (5 mM) and LPS (1 µg/mL)-induced in the supernatant of the cultures, without affecting the intracellular levels of their precursors.
In Vivo

NLRP3-IN-9 (3, 10 mg/kg; i.p.) reduces inflammation and mechanical hyperalgesia in a mouse model of acute gout[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-4 month old male and female C57BL/6J WT and NLRP3-KO mice[1]
Dosage: 3, 10 mg/kg
Administration: I.p.
Result: Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
Molecular Weight

374.39

Formula

C16H19N2NaO5S
CAS No.
SMILES

O=C(N([Na])S(C1=CC(C(C)(O)C)=CO1)(=O)=O)NC2=CC(C)=CC(C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-92768759-64-2NOD-like Receptor (NLR)anti-inflammatoryIL-1βmacrophagesgoutCasp-1 p10Inhibitorinhibitorinhibit

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