AFM

By Targets:	Fluorescent Dye (1) Influenza Virus (2) Protein Arginine Deiminase (4) Small Interfering RNA (siRNA) (1) TNF Receptor (1)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (6)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125099A

AFM-30a hydrochloride	Protein Arginine Deiminase	Inflammation/Immunology Cancer
AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC₅₀ value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC₅₀ value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis .

HY-P990314

AFM24		Inflammation/Immunology
AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 74.5 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-136557A

AFM32a hydrochloride 1 Publications Verification PAD2-IN-1 hydrochloride	Protein Arginine Deiminase	Inflammation/Immunology Cancer
AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) .

HY-D0029

5(6)-Aminofluorescein 1 Publications Verification 5(6)-AFM; Fluoresceinamine mixed isomers	Fluorescent Dye	Others
5(6)-Aminofluorescein (5(6)-AFM) is a a precursor for synthesis of 5(6)-FITC (HY-15941). 5(6)-FITC is an amine-reactive derivative of fluorescein dye.

HY-N0638

Dendrobine 2 Publications Verification	Influenza Virus	Infection
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively .

HY-125099

AFM-30a	Protein Arginine Deiminase	Inflammation/Immunology Cancer
AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC₅₀ value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC₅₀ value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis .

HY-RS00433

AFM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AFM Human Pre-designed siRNA Set A contains three designed siRNAs for AFM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AFM Human Pre-designed siRNA Set A AFM Human Pre-designed siRNA Set A

HY-136557

AFM32a PAD2-IN-1	Protein Arginine Deiminase	Inflammation/Immunology Cancer
AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) .

HY-P990710

Acimtamig AFM13	TNF Receptor	Inflammation/Immunology
Acimtamig is an anti-TNFRSF8/FCGR3A monoclonal antibody .

HY-N0638R

Dendrobine (Standard)	Influenza Virus	Infection
Dendrobine (Standard) is the analytical standard of Dendrobine. This product is intended for research and analytical applications. Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively .

Cat. No.	Product Name	Type

HY-D0029

5(6)-Aminofluorescein 1 Publications Verification 5(6)-AFM; Fluoresceinamine mixed isomers	Fluorescent Dyes/Probes
5(6)-Aminofluorescein (5(6)-AFM) is a a precursor for synthesis of 5(6)-FITC (HY-15941). 5(6)-FITC is an amine-reactive derivative of fluorescein dye.

Cat. No.	Product Name	Target	Research Area

HY-P990314

AFM24		Inflammation/Immunology
AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 74.5 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990710

Acimtamig AFM13	TNF Receptor	Inflammation/Immunology
Acimtamig is an anti-TNFRSF8/FCGR3A monoclonal antibody .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0638

Dendrobine 2 Publications Verification	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Orchidaceae Source classification Plants Disease Research Fields Dendrobium nobile Lindl.	Influenza Virus
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively .

HY-N0638R

Dendrobine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Orchidaceae Source classification Plants Dendrobium nobile Lindl.	Influenza Virus
Dendrobine (Standard) is the analytical standard of Dendrobine. This product is intended for research and analytical applications. Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively .

Species:	Human (3) Virus (11)
Tag:	His (13) Tag Free (1)
Source:	HEK293 (9) Sf9 insect cells (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70036

	*Afamin/AFM* Protein, Human (HEK293, His)** rHuAfamin, His; Afamin; AFM; ALB2; ALB2alpha-Alb; ALBA; ALBAalpha-albumin; ALF; Alpha-Alb; Alpha-albumin	Human	HEK293
	Afamin/AFM Protein, Human (578a.a, HEK 293, His) is a specificl human vitamin E-binding glycoprotein that is present in biological fluids. Afamin Protein, Human plays potential role in fertility and neuroprotection.

HY-P70036B

	*Afamin/AFM* Protein, Human (587a.a, HEK293, His)** rHuAfamin, His; Afamin; AFM; ALB2; ALB2alpha-Alb; ALBA; ALBAalpha-albumin; ALF; Alpha-Alb; Alpha-albumin	Human	HEK293
	Afamin/AFM protein serves as a carrier of hydrophobic molecules in body fluids and plays an important role in the solubility and activity of lipidated Wnt family members (including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, and WNT9B). The role of WNT10A and WNT10B. It also binds to vitamin E and may act as a transporter of this vitamin in body fluids, especially when the lipoprotein system is deficient. Afamin/AFM Protein, Human (578a.a, HEK293, His) is the recombinant human-derived Afamin/AFM protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P74119

	*envelope glycoprotein gp120 Protein, HIV-1 (AFM77980, HEK293, His)* Envelope glycoprotein gp160; Env polyprotein; gp120; gp41; env	Virus	HEK293
	envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope.Gp120 is essential for viral infection as it facilitates HIV entry into the host cell.gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus.envelope glycoprotein gp120 Protein, HIV-1 (AFM77980, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74014

	*HA/Hemagglutinin Protein, H3N2 (AFM72872, sf9, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H3N2 (A/Guangdong-Luohu/1256/2009, sf9, His)	Virus	Sf9 insect cells
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA/Hemagglutinin Protein, H3N2 (AFM72872, 530a.a, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74673

	*Nucleoprotein/NP Protein, H3N2 (AFM71861, sf9, His)* Influenza A H3N2 (A/Aichi/2/1968) Nucleoprotein / NP Protein (sf9, His)	Virus	Sf9 insect cells
	Influenza virus nucleoprotein (NP) is a structural protein that coats viral negative-strand RNA.NP proteins protect viral RNA from degradation by cellular enzymes during the viral life cycle, fit the helical structure of RNP, regulate transcription and replication of viral RNA templates in a histone-like manner, and induce immunosuppression during infection.Nucleoprotein/NP Protein, H3N2 (AFM71861, sf9, His) is the recombinant Virus-derived Nucleoprotein/NP protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75103

	*HA/Hemagglutinin Protein, H3N2 (AFM72164, sf9, His)* Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin / HA Protein (sf9, His)	Virus	Sf9 insect cells
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA/Hemagglutinin Protein, H3N2 (AFM72164, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74967

	*HA1/Hemagglutinin Protein, H3N2 (AFM72164, HEK293, His)* Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H3N2 (AFM72164, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74968

	*HA1/Hemagglutinin Protein, H3N2 (AFM71967, HEK293, His)* Influenza A H3N2 (A/Victoria/3/1975) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H3N2 (AFM71967, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74969

	*HA1/Hemagglutinin Protein, H3N2 (AFM71912, HEK293, His)* Influenza A H3N2 (A/England/42/1972) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H3N2 (AFM71912, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74971

	*HA1/Hemagglutinin Protein, H3N2 (AFM71754, HEK293, His)* Influenza A H3N2 (A/Wisconsin/15/2009) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H3N2 (AFM71754, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74966

	*HA1/Hemagglutinin Protein, H3N2 (AFM72872, HEK293, His)* Influenza A H3N2 (A/Guangdong-Luohu/1256/2009) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA1/Hemagglutinin Protein, H3N2 (AFM72872, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74970

	*HA1/Hemagglutinin Protein, H3N2 (AFM71868, HEK293, His)* Influenza A H3N2 (A/New York/55/2004) Hemagglutinin / HA1 Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H3N2 (AFM71868, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P72328

	H2AC4 Protein, Human " Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; H2AFM"	Human	E. coli
	The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free. The total length of H2AC4 Protein, Human is 129 a.a., with molecular weight of ~14.0 kDa.

HY-P74760

	*Matrix Protein 1/M1 Protein, H3N2 (AFM71858, His)* Influenza A H3N2 (A/Aichi/2/1968) Matrix protein 1 / M1 Protein (His)	Virus	E. coli
	Matrix protein 1/M1 Protein is pivotal in virus replication, spanning entry, uncoating, assembly, and budding.Binding to ribonucleocapsids inhibits viral transcription, and interaction with NEP aids nuclear export.M1 forms a shell on the inner virion membrane, binding the RNP.During entry, M1 dissociates from the RNP, allowing nuclear transport for transcription.M1 influences virion shape, determining infectivity, with filamentous virions crucial for cell-to-cell spread and spherical virions for aerosol-based transmission.Matrix Protein 1/M1 Protein, H3N2 (AFM71858, His) is the recombinant Virus-derived Matrix protein 1/M1 protein, expressed by E.coli , with N-His labeled tag.

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HY-P83299

	Acetyl-Histone H2A Antibody (YA3044) H2AK9ac; H2A; H2A1B; H2AFM; HIST1H2A; Histone H2A.2; Histone H2A/a	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Acetyl-Histone H2A Antibody (YA3044) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3044), targeting Acetyl-Histone H2A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). Acetyl-Histone H2A Antibody (YA3044) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS00433

AFM Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AFM Human Pre-designed siRNA Set A contains three designed siRNAs for AFM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Natural
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Recombinant Proteins

Antibodies

Oligonucleotides

AFM

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products