2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. AFM24

AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 74.5 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

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Based on 1 publication(s) in Google Scholar

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Description

AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 74.5 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Bispecific

IC50 & Target

EGFR & Fc-gamma-RIIIA
Molecular Weight

196340.00

Appearance

Liquid

Color

Colorless to light yellow

Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Fc gamma RIIA/CD32a Protein, Human can bind AFM24. The EC50 for this effect is 93.45 ng/mL.
  • Immobilized EGFR Protein, Human can bind AFM24. The EC50 for this effect is 86.89 ng/mL.
Purity & Documentation
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AFM24 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFM24AFM 24AFM-24EGFREpidermal growth factor receptorErbB-1HER1Bispecific AntibodyEGFR & Fc-gamma-RIIIA AntibodyInhibitorinhibitorinhibit

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