2. Epigenetics
  3. Protein Arginine Deiminase
  4. AFM32a

AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (AFM32a hydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

AFM32a Chemical Structure

AFM32a Chemical Structure

CAS No. : 2095109-82-1

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Other Forms of AFM32a:

AFM32a Related Antibodies

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Description

AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50 & Target

Protein Arginine Deiminase 2 (PAD2)[1]
In Vitro

In the target engagement assay, the EC 50 of AFM32a (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of AFM32a overcomes its relatively poor ability to enter cells[1].
AFM32a (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AFM32a Related Antibodies
Molecular Weight

480.53

Formula

C25H29FN6O3
CAS No.
SMILES

O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AFM32a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFM32a2095109-82-1PAD2-IN-1Protein Arginine DeiminasePeptidylarginine DeiminasePAD2benzimidazole-basedhistoneH3citrullinationtargetengagementInhibitorinhibitorinhibit

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