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Results for "

APAF1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

5

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125018
    QM31

    SVT016426

    		 Caspase Cancer
    QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint [1] .
    QM31
  • HY-18633
    MDK83190

    		Apoptosis Cancer
    MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner [1].
    MDK83190
  • HY-103349
    PETCM
    1 Publications Verification

    		 Caspase Apoptosis Cancer
    PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells [1] .
    PETCM
  • HY-100472
    ZYZ-488

    		Caspase Cancer
    ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 [1].
    ZYZ-488
  • HY-126741
    Azadirachtin
    2 Publications Verification

    		 Apoptosis Parasite NF-κB Bcl-2 Family Caspase Infection Inflammation/Immunology Cancer
    Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells [1] .
    Azadirachtin
  • HY-Y0598
    trans-Chalcone

    		Fatty Acid Synthase (FASN) Apoptosis Fungal Inflammation/Immunology Cancer
    trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity [1] .
    trans-Chalcone
  • HY-RS00801
    APAF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    APAF1 Human Pre-designed siRNA Set A contains three designed siRNAs for APAF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    APAF1 Human Pre-designed siRNA Set A
    APAF1 Human Pre-designed siRNA Set A

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