Search Result

Isoforms Recommended:	Caspase 9

Results for "

Caspase 9

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (24) Akt (2) Apoptosis (31) Arenavirus (2) Autophagy (4) Bacterial (1) Bcl-2 Family (6) Beta-secretase (2) CDK (2) Cholinesterase (ChE) (2) Drug Metabolite (1) Endogenous Metabolite (3) Fatty Acid Synthase (FASN) (2) FKBP (1) Fluorescent Dye (1) IAP (2) Integrin (2) Interleukin Related (1) Keap1-Nrf2 (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (1) NF-κB (2) P-glycoprotein (1) p38 MAPK (1) PARP (4) Polo-like Kinase (PLK) (1) Reactive Oxygen Species (2) STAT (1)
By Research Areas:	Cancer (37) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (5) Neurological Disease (7)

By Targets:

Caspase (24)

Akt (2)

Apoptosis (31)

Arenavirus (2)

Autophagy (4)

Bacterial (1)

Bcl-2 Family (6)

Beta-secretase (2)

CDK (2)

Cholinesterase (ChE) (2)

Drug Metabolite (1)

Endogenous Metabolite (3)

Fatty Acid Synthase (FASN) (2)

FKBP (1)

Fluorescent Dye (1)

IAP (2)

Integrin (2)

Interleukin Related (1)

Keap1-Nrf2 (2)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

MMP (1)

NF-κB (2)

P-glycoprotein (1)

p38 MAPK (1)

PARP (4)

Polo-like Kinase (PLK) (1)

Reactive Oxygen Species (2)

STAT (1)

By Research Areas:

Cancer (37)

Cardiovascular Disease (2)

Infection (1)

Inflammation/Immunology (5)

Neurological Disease (7)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Antibodies

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136744

Caspase-9 Inhibitor III Ac-LEHD-cmk	Caspase	Cardiovascular Disease
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a *caspase-9* inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury .

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-N0605

Ginsenoside Rh2 3 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-121320

Raptinal 5 Publications Verification	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates *caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9* .

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dye	Cancer
FITC-C6-LEHD-FMK, a fluorescently labeled *caspase-9* inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

HY-D1652

Ac-LEHD-AMC	Caspase	Others
Ac-LEHD-AMC is a fluorogenic substrate for *caspase-9* (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .

HY-P4392

Z-VAD-AMC	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-N2632

Uvarigrin	Apoptosis	Cancer
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-P10326

Z-ATAD-FMK	Caspase Apoptosis	Cancer
Z-ATAD-FMK is an inhibitor of *caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis* by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .

HY-N3376

Liriodenine Spermatheridine; VLT045	Apoptosis	Cancer
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

HY-N6861

Lucidenic acid B	Apoptosis	Cancer
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-13945

NVP 231 2 Publications Verification	Apoptosis	Cancer
NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC₅₀=12 nM) that competitively inhibits binding of ceramide to CerK . NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage .

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard); Ginsenoside-Rh2 (Standard)	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-P1010

Z-LEHD-FMK 5+ Cited Publications	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK is a selective and irreversible inhibitor of *caspase-9*, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-P1010A

Z-LEHD-FMK TFA	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of *caspase-9*, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-N13123

Tenacissoside C	Apoptosis	Cancer
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-129478

TC11	Caspase Bcl-2 Family CDK	Cancer
TC11 is a MCL1 degrader. TC11 is also a *Caspase-9* and CDK1 activator. TC11 structurally relates to immunomodulatory agents as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Apoptosis	Cancer
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N11648

Ganoderic acid T1	Apoptosis Caspase	Inflammation/Immunology Cancer
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-N1970

5,7-Dihydroxychromone 1 Publications Verification	Keap1-Nrf2 Arenavirus Caspase PARP	Neurological Disease
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated *caspase-3* and *caspase-9* and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-N10481

Aviculin	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator *caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP*). Aviculin shows an increase in the Bax/Bcl-2 ratio .

HY-125018

QM31 SVT016426	Caspase	Cancer
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC₅₀=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint .

HY-N0702

Tenuifolin	Beta-secretase Cholinesterase (ChE)	Neurological Disease
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD) .

HY-167825

Barakol	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-W046353R

2-Methoxycinnamaldehyde (Standard)	Apoptosis	Cancer
2-Methoxycinnamaldehyde (Standard) is the analytical standard of 2-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-13559A

Atiprimod dimaleate Azaspirane dimaleate; SKF 106615-12 dimaleate; SKF 106615A12 dimaleate	Apoptosis Caspase STAT Interleukin Related
Atiprimod (Azaspirane) (dimaleate) is an anti-proliferative and anti-angiogenic agent that inhibits proliferation of cancer cell lines. Atiprimod (dimaleate) also induces Apoptosis and activates both caspase-9 and caspase-3 in T84 colon carcinoma cells. Atiprimod (dimaleate) inhibits both bFGF and VEGF induced proliferation and migration of human umbilical vein endothelial cells, resulting in disruption of cord formation. Atiprimod (dimaleate) reduces production of IL-6, VEGF and inhibits activation of Stat3 .

HY-111244

DCB-3503	Others	Others
DCB-3503 is a small molecule inhibitor of cell cycle progression, which has the activity of inducing G?/G? phase arrest and apoptosis in human hepatoma cells. DCB-3503 can inhibit the proliferation of human hepatoma cells, induce cell cycle arrest and apoptosis, and its mechanism is related to downregulating cyclin-dependent kinase (CDK) 2, CDK4 and CDK6, while activating PARP, caspase-3, caspase-9 and Bax, and downregulating Bcl-2.

HY-116204

SKLB70326	Others	Others
SKLB70326 is a small molecule inhibitor of cell cycle progression, which has the activity of inducing G?/G? phase arrest and apoptosis in human hepatoma cells. SKLB70326 can inhibit the proliferation of human hepatoma cells, induce cell cycle arrest and apoptosis, and its mechanism is related to downregulating cyclin-dependent kinase (CDK) 2, CDK4 and CDK6, while activating PARP, caspase-3, caspase-9 and Bax, and downregulating Bcl-2.

HY-109583

4-Oxofenretinide 4-Oxo-4-HPR	Apoptosis Reactive Oxygen Species Drug Metabolite	Cancer
4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .

HY-117047

ALC67	Apoptosis Caspase	Cancer
ALC67 is a cytotoxic thiazolidine compound with an IC₅₀ of approximately 5 μM against liver, breast cancer, colon cancer, and endometrial cancer cell lines. ALC67 induces apoptosis in cancer cells by activating *caspase-9* and causing cell cycle arrest at the SubG1/G1 phase, via a pathway that is independent of death receptors. ALC67 can be used in cancer research .

HY-N0702R

Tenuifolin (Standard)	Beta-secretase Cholinesterase (ChE)	Neurological Disease
Tenuifolin (Standard) is the analytical standard of Tenuifolin. This product is intended for research and analytical applications. Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD) .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Keap1-Nrf2 Arenavirus Caspase PARP	Neurological Disease
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone. This product is intended for research and analytical applications. 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-17473

Embelin 4 Publications Verification Embelic acid; Emberine; NSC 91874	IAP NF-κB Apoptosis Autophagy	Cancer
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-149540

CTL-06	Fatty Acid Synthase (FASN)	Cancer
CTL-06 is an inhibitor of Fatty Acid Synthase (FASN) (IC₅₀: 3 μM) and can induce apoptosis. CTL-12 blocks the cell cycle in the Sub-G1/S phase, upregulates the expression of caspase-9 and the apoptosis marker Bax, and downregulates the anti-apoptotic marker Bcl-xL. CTL-12 inhibits de novo lipogenesis, blocks the metabolic demands of tumor cells, and is commonly used in breast and colorectal cancer research .

HY-149541

CTL-12	Fatty Acid Synthase (FASN)	Cancer
CTL-12 is an inhibitor of fatty acid synthase (FASN) (IC₅₀: 2.5 μM) and can induce apoptosis. CTL-12 blocks the cell cycle in the Sub-G1/S phase, upregulates the expression of caspase-9 and the apoptosis marker Bax, and downregulates the anti-apoptotic marker Bcl-xL. CTL-12 inhibits de novo lipogenesis, blocks the metabolic demands of tumor cells, and is commonly used in breast and colorectal cancer research .

HY-101999

EM20-25	Bcl-2 Family Caspase Apoptosis	Cancer
EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069) .

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-17473R

Embelin (Standard)	IAP NF-κB Apoptosis Autophagy	Cancer
Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-130326

RAPTA-C Ru(η6-p-cymene)Cl2(pta)	Apoptosis Caspase	Cardiovascular Disease Cancer
RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model .

HY-N0905

Ginsenoside Rh4	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite	Cancer
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and *caspase 9. Ginsenoside Rh4 also induces autophagy*.

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-16046

Rimiducid Maximum Cited Publications 34 Publications Verification AP1903	FKBP Apoptosis	Cancer
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

HY-162895

NL13	Polo-like Kinase (PLK) Akt CDK Caspase Apoptosis	Cancer
NL13 is a Polo-like kinase 4 (PLK4) inhibitor with an IC₅₀ value of 2.32 μM. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC₅₀ values of 3.51 μM and 2.53 μM, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth .

HY-167707

Q-VD(OMe)-OPh	Others	Cancer
Q-VD(OMe)-OPh is a broad-spectrum caspase inhibitor with high activity in inhibiting apoptosis. Q-VD(OMe)-OPh is not toxic to cells at high concentrations, demonstrating its safety. Q-VD(OMe)-OPh exhibits comparable effectiveness to other widely used inhibitors in preventing apoptosis mediated by caspase 9/3, caspase 8/10, and caspase 12 .

HY-106789

Plaunotol CS-684	Bacterial	Infection Inflammation/Immunology Cancer
Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .

HY-147897

Apoptosis inducer 9	Apoptosis	Cancer
Apoptosis inducer 9 induces apoptosis with IC₅₀ value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents .

HY-101597

NVX-207	Apoptosis	Cancer
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC₅₀=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP .

HY-124083

MPT0B214	Microtubule/Tubulin Apoptosis Caspase Mitochondrial Metabolism	Cancer
MPT0B214 is a microtubule inhibitor that strongly binds to the colchicine binding site of tubulin, preventing tubulin polymerization. MPT0B214 induces apoptosis through a mitochondrial/caspase 9 dependent pathway and shows cytotoxicity across various human tumor cell lines. MPT0B214 can be used for cancer research .

HY-114250

Cantrixil TRX-E-002-1	Apoptosis	Cancer
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes .

Cat. No.	Product Name	Type

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Chromogenic Substrates
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dyes/Probes
FITC-C6-LEHD-FMK, a fluorescently labeled *caspase-9* inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P1010

Z-LEHD-FMK Maximum Cited Publications 10 Publications Verification	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK is a selective and irreversible inhibitor of *caspase-9*, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P4392

Z-VAD-AMC	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-P10326

Z-ATAD-FMK	Caspase Apoptosis	Cancer
Z-ATAD-FMK is an inhibitor of *caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis* by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .

HY-P5348

Ac-LEHD-pNA	Peptides	Others
Ac-LEHD-pNA is a biological active peptide. (Caspase-9 substrate; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.)

HY-P1010A

Z-LEHD-FMK TFA	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of *caspase-9*, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80050

	Caspase-9 Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	Caspase-9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 46 kDa, targeting to Caspase-9. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P80964

	*Cleaved-Caspase 9* Antibody**	WB, IP	Human, Mouse
	Cleaved-Caspase 9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 46 kDa, targeting to Cleaved-Caspase 9. It can be used for WB, IP assays with tag free, in the background of Human, Mouse.

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