2. Anti-infection
  3. Bacterial
  4. Plaunotol

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .

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Plaunotol Chemical Structure

Plaunotol Chemical Structure

CAS No. : 64218-02-6

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Plaunotol Related Antibodies

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Description

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer [1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer [2].

In Vitro

Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1[2].
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1[2].
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Plaunotol Related Antibodies

Cell Proliferation Assay[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 0, 10, 20, or 40 μM
Incubation Time: 24 or 48 h
Result: Inhibited the proliferation of human colon cancer cell line DLD1 after 48 h.

Apoptosis Analysis[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 40 μM
Incubation Time: 24 or 48 h
Result: Caused a significant increase in the population of Annexin V [+] apoptotic cells.

Western Blot Analysis[2]

Cell Line: human colon cancer cell line DLD1
Concentration: 40 μM
Incubation Time: 48 h
Result: Induced PARP cleavage, and showed activation of caspase-3.
In Vivo

Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) significantly alleviates gastric mucosal damage in male Wistar rats treated with C48/80 [3].
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 [3].
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[3]
Dosage: 10, 25 or 50 mg/kg
Administration: Oral administration
Result: Plaunotol attenuated the severity of the gastric mucosal lesions.
Molecular Weight

306.48

Formula

C20H34O2
CAS No.
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(CO)=C/CC/C(C)=C/CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Plaunotol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plaunotol64218-02-6CS-684CS684CS 684Bacterialorally activetopical applicationhuman colon cancer cell line DLD1antigastritiscolon cancerInhibitorinhibitorinhibit

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