2. Apoptosis
  3. Apoptosis Caspase
  4. RAPTA-C

RAPTA-C  (Synonyms: Ru(η6-p-cymene)Cl2(pta))

Cat. No.: HY-130326 Purity: 99.30%
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RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model.

For research use only. We do not sell to patients.

RAPTA-C Chemical Structure

RAPTA-C Chemical Structure

CAS No. : 372948-28-2

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1 mg USD 85 In-stock
5 mg USD 207 In-stock
10 mg USD 305 In-stock
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Based on 1 publication(s) in Google Scholar

RAPTA-C Related Antibodies

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Description

RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model[1][2][3].

Molecular Weight

460.32

Formula

C16H23Cl2N3PRu
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

CC12=C3[Ru+2]145(C6=C52)(P78C[N@@](C9)C[N@@](C[N@@]9C8)C7)([Cl-])([Cl-])C6(C(C)C)=C43
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (54.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1724 mL 10.8620 mL 21.7240 mL
5 mM 0.4345 mL 2.1724 mL 4.3448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1724 mL 10.8620 mL 21.7240 mL 54.3100 mL
5 mM 0.4345 mL 2.1724 mL 4.3448 mL 10.8620 mL
10 mM 0.2172 mL 1.0862 mL 2.1724 mL 5.4310 mL
15 mM 0.1448 mL 0.7241 mL 1.4483 mL 3.6207 mL
20 mM 0.1086 mL 0.5431 mL 1.0862 mL 2.7155 mL
25 mM 0.0869 mL 0.4345 mL 0.8690 mL 2.1724 mL
30 mM 0.0724 mL 0.3621 mL 0.7241 mL 1.8103 mL
40 mM 0.0543 mL 0.2716 mL 0.5431 mL 1.3578 mL
50 mM 0.0434 mL 0.2172 mL 0.4345 mL 1.0862 mL
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RAPTA-C Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RAPTA-C372948-28-2Ru(η6-p-cymene)Cl2(pta)ApoptosisCaspaseanti-canceranti-angiogenicanti-metastaticG(2)/M phase arrestp53apoptotic,ovarian carcinomaInhibitorinhibitorinhibit

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