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CoREST

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HDAC (2) Histone Demethylase (5) Monoamine Oxidase (3)
By Research Areas:	Cancer (6) Metabolic Disease (1)

7

Inhibitors & Agonists

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TNG260	HDAC	Cancer
TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing .

(S)-TNG260	HDAC	Cancer
(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.

LSD1-IN-31	Histone Demethylase	Metabolic Disease
LSD1-IN-31 (compound 11e) can directly bind to LSD1/CoREST complex to reduce LSD1 demethylation enzymatic activity. LSD1-IN-31 inhibits LSD1 demethylation activity and influences its downstream IκB/NF-κB signaling pathway. LSD1-IN-31 inhibits osteoclastic bone loss in vitro and in vivo. LSD1-IN-31 can be used for osteoporosis research .

TCP-MP-CA	Histone Demethylase	Cancer
TCP-MP-CA (compound 11a) is an inhibitor of LSD1 demethylation enzymatic via binding to LSD1/CoREST complex. TCP-MP-CA exhibits an inhibitory effect on osteoclastogenesis, with an IC₅₀ value of 0.14 µM .

LSD1-IN-15	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit *LSD1-CoREST, MAO-A* and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM .

LSD1-IN-16	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit *LSD1-CoREST, MAO-A* and MAO-B, with IC₅₀ values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 15.2 μM .

LSD1-IN-17	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit *LSD1-CoREST, MAO-A* and MAO-B, with IC₅₀ values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 17.2 μM .

Cat. No.	Compare	Product Name	Application	Reactivity

	CoREST Antibody (YA1813) CoREST; Nr2b2; RCOR; Rcor1; Rxrb	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	CoREST Antibody (YA1813) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1813), targeting CoREST, with a predicted molecular weight of 53 kDa (observed band size: 66 kDa). CoREST Antibody (YA1813) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

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