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Isoforms Recommended:	Kinesin-5/Eg5/KSP

Results for "

Eg5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Apoptosis (4) Drug-Linker Conjugates for ADC (1) Kinesin (18) Microtubule/Tubulin (2)
By Research Areas:	Cancer (20)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112915

Eg5 Inhibitor V, trans-24	Kinesin	Cancer
Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC₅₀ of 0.65 μM, and can be used in the research of cancer.

HY-160441

MC-Val-Cit-PAB-Ispinesib	Kinesin	Cancer
MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent inhibitor of *Eg5*. MC-Val-Cit-PAB-Ispinesib is a click chemistry reagent .

HY-122247

PVZB1194	Kinesin	Cancer
PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein *Eg5* or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity .

HY-19944

Dimethylenastron 3 Publications Verification	Kinesin	Cancer
Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC₅₀ of 200 nM.

HY-W011102

S-Trityl-L-cysteine NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine	Kinesin Apoptosis	Cancer
S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC₅₀ of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities .

HY-12069

SB-743921 hydrochloride 3 Publications Verification	Kinesin	Cancer
SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a K_i of 0.1 nM.

HY-157078

Eg5-IN-2	ADC Cytotoxin	Cancer
Eg5-IN-2 (Compound Scaffold B (4)) is an *Eg5* inhibitor (IC₅₀: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs .

HY-162518

Eg5-IN-3	Kinesin Microtubule/Tubulin	Cancer
Eg5-IN-3 (5) is an *Eg5* inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A) .

HY-155134

Eg5-IN-1	Kinesin	Cancer
Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor with an IC₅₀ value of 1.97 µM. Eg5-IN-1 can be used in research of cancer .

HY-119407

Terpendole E	Kinesin	Cancer
Terpendole E is a mitotic kinesin *Eg5* inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

HY-14846A

Litronesib Racemate LY2523355 Racemate	Kinesin	Others
Litronesib Racemate (LY2523355 Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5 .

HY-14846

Litronesib 1 Publications Verification LY2523355	Kinesin	Cancer
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity .

HY-19966

K858 (Racemic)	Kinesin Apoptosis	Cancer
K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC₅₀ of 1.3 μM.

HY-101071A

Monastrol 4 Publications Verification (±)-Monastrol	Kinesin Apoptosis	Cancer
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC₅₀ value of 14 μM.

HY-124823

Monastroline HR22C16	Others	Others
Monastroline (HR22C16) is an effective and selective inhibitor of the mitotic kinesin Eg5, exhibiting strong cell permeability.

HY-16062

ARQ 621	Kinesin	Cancer
ARQ 621 is an allosteric, potent and selective inhibitor of *Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity . ARQ 621 is a kinesin* inhibitor . ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-157079

LP-6	Drug-Linker Conjugates for ADC	Cancer
LP-6 is a Drug-Linker Conjugates for ADC, and can be used for synthesis of ADCs. LP-6 consists of an Eg5 inhibitor and a linker .

HY-13224

AZD4877	Kinesin Apoptosis	Cancer
AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC₅₀ of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity ^[5].

HY-110208

BRD9876 1 Publications Verification	Kinesin Microtubule/Tubulin	Cancer
BRD9876 is the “rigor” inhibitor that locks **kinesin-5 (Eg5)** in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research .

HY-101071

(S)-Monastrol (+)-Monastrol	Kinesin	Cancer
(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin *Eg5* that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles .

HY-14661

SB-743921 free base	Kinesin	Cancer
SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a K_i of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases .

HY-13224A

AZD4877 hydrochloride	Others	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

Terpendole E	Structural Classification Microorganisms Iridoids Terpenoids Source classification	Kinesin
Terpendole E is a mitotic kinesin *Eg5* inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701378

	KIF11 Protein, Human KIF11; Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free. The total length of KIF11 Protein, Human is 368 a.a., .

HY-P701379

	KIF11 Protein, Human (His) KIF11; Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human (His) is the recombinant human-derived KIF11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of KIF11 Protein, Human (His) is 368 a.a., .

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HY-P80647

	Eg5 Antibody (YA776) KIF11; Eg5; KNSL1; TRIP5; Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5	WB, ICC/IF, IP	Human
	Eg5 Antibody (YA776) is a non-conjugated and Mouse origined monoclonal antibody about 119 kDa, targeting to Eg5 (4H3). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human.

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Cat. No.	Product Name		Classification

HY-16062

ARQ 621		Alkynes
ARQ 621 is an allosteric, potent and selective inhibitor of *Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity . ARQ 621 is a kinesin* inhibitor . ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Eg5

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