Eg5 Inhibitor V, trans-24

Name: Eg5 Inhibitor V, trans-24
Brand: MedChemExpress
SKU: HY-112915
Rating: 4.5 (1 reviews)

Cat. No.: HY-112915 Purity: 98.18%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC₅₀ of 0.65 μM, and can be used in the research of cancer.

For research use only. We do not sell to patients.

Eg5 Inhibitor V, trans-24 Chemical Structure

CAS No. : 869304-55-2

Size	Price	Stock	Quantity
1 mg	USD 388	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 892	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

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View All Kinesin Isoform Specific Products:

View All Isoforms

Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

Biological Activity
Purity & Documentation
References
Customer Review

Description

Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC₅₀ of 0.65 μM, and can be used in the research of cancer.

IC₅₀ & Target^[1]

Eg5

0.65 μM (IC₅₀)

In Vitro

Eg5 Inhibitor V, trans-24 is a potent and specific Eg5 inhibitor with an IC₅₀ of 0.65 μM, and can be used in the research of cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

423.46

Formula

C₂₆H₂₁N₃O₃

CAS No.

869304-55-2

Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@]1([H])CC2=C([C@@H](C3=CC=CC(O)=C3)N14)NC5=C2C=CC=C5)N(CC6=CC=CC=C6)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 45 mg/mL (106.27 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3615 mL	11.8075 mL	23.6150 mL
5 mM	0.4723 mL	2.3615 mL	4.7230 mL
10 mM	0.2361 mL	1.1807 mL	2.3615 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.18%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (257 KB) HNMR (224 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Sunder-Plassmann N, et al. Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. Bioorg Med Chem. 2005 Nov 15;13(22):6094-111. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3615 mL	11.8075 mL	23.6150 mL	59.0375 mL
	5 mM	0.4723 mL	2.3615 mL	4.7230 mL	11.8075 mL
	10 mM	0.2361 mL	1.1807 mL	2.3615 mL	5.9037 mL
	15 mM	0.1574 mL	0.7872 mL	1.5743 mL	3.9358 mL
	20 mM	0.1181 mL	0.5904 mL	1.1807 mL	2.9519 mL
	25 mM	0.0945 mL	0.4723 mL	0.9446 mL	2.3615 mL
	30 mM	0.0787 mL	0.3936 mL	0.7872 mL	1.9679 mL
	40 mM	0.0590 mL	0.2952 mL	0.5904 mL	1.4759 mL
	50 mM	0.0472 mL	0.2361 mL	0.4723 mL	1.1807 mL
	60 mM	0.0394 mL	0.1968 mL	0.3936 mL	0.9840 mL
	80 mM	0.0295 mL	0.1476 mL	0.2952 mL	0.7380 mL
	100 mM	0.0236 mL	0.1181 mL	0.2361 mL	0.5904 mL