2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. PVZB1194

PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein Eg5 or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity.

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PVZB1194 Chemical Structure

PVZB1194 Chemical Structure

CAS No. : 1141768-04-8

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25 mg USD 110 In-stock
50 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

PVZB1194 Related Antibodies

Top Publications Citing Use of Products

View All Kinesin Isoform Specific Products:

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Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

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Description

PVZB1194 is a biphenyl-type inhibitor of Kinesin spindle protein Eg5 or KIF11. Eg5 is related to the cell cycle, and Eg5 inhibition can lead to cell cycle arrest and apoptosis. PVZB1194 exhibits anticancer potential via inhibiting Eg5 ATPase activity. PVZB1194 binds to the α4/α6 allosteric pocket, and shows ATP competetive activity[1].

IC50 & Target[1]

Eg5

 

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
5.5 μM
Compound: 16, PVZB1194
Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
[PMID: 19167222]
Molecular Weight

319.27

Formula

C13H9F4NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (783.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1321 mL 15.6607 mL 31.3215 mL
5 mM 0.6264 mL 3.1321 mL 6.2643 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1321 mL 15.6607 mL 31.3215 mL 78.3036 mL
5 mM 0.6264 mL 3.1321 mL 6.2643 mL 15.6607 mL
10 mM 0.3132 mL 1.5661 mL 3.1321 mL 7.8304 mL
15 mM 0.2088 mL 1.0440 mL 2.0881 mL 5.2202 mL
20 mM 0.1566 mL 0.7830 mL 1.5661 mL 3.9152 mL
25 mM 0.1253 mL 0.6264 mL 1.2529 mL 3.1321 mL
30 mM 0.1044 mL 0.5220 mL 1.0440 mL 2.6101 mL
40 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9576 mL
50 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5661 mL
60 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3051 mL
80 mM 0.0392 mL 0.1958 mL 0.3915 mL 0.9788 mL
100 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.7830 mL
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PVZB1194 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PVZB11941141768-04-8PVZB 1194PVZB-1194Kinesinbiphenyl-typeATP competetiveanticancerInhibitorinhibitorinhibit

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