Eg5-IN-3

Cat. No.: HY-162518: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).

For research use only. We do not sell to patients.

Eg5-IN-3 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Kinesin Isoform Specific Products:

View All Isoforms

Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

Biological Activity
Purity & Documentation
References
Customer Review

Description	Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A)^[1].
In Vitro	Eg5-IN-3 (5) inhibits cancer cell Eg5 ATPase at an IC₅₀ of 2.37 ± 0.15 µM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Eg5-IN-3 Related Antibodies
Molecular Weight	429.47
Formula	C₂₃H₂₃N₇O₂
SMILES	CN1C(N=C(NCCCN2C=NC=C2)N3CC4=CC=C(C=CC=C5)C5=C4)=C3C(NC1=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Samia A Elseginy, et al. Identifying and characterising promising small molecule inhibitors of kinesin spindle protein using ligand-based virtual screening, molecular docking, molecular dynamics and MM‑GBSA calculations. J Comput Aided Mol Des. 2024 Apr 1;38(1):16. [Content Brief]

Eg5-IN-3 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eg5-IN-3KinesinMicrotubule/TubulinEg5Binding free energyMolecular dynamicsbipolar spindlesmitotic phaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Eg5-IN-3

Eg5-IN-3 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Kinesin Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review