2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin Microtubule/Tubulin
  4. Eg5-IN-3

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).

For research use only. We do not sell to patients.

Eg5-IN-3 Chemical Structure

Eg5-IN-3 Chemical Structure

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Eg5-IN-3 Related Antibodies

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Description

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A)[1].

In Vitro

Eg5-IN-3 (5) inhibits cancer cell Eg5 ATPase at an IC50 of 2.37 ± 0.15 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eg5-IN-3 Related Antibodies
Molecular Weight

429.47

Formula

C23H23N7O2
SMILES

CN1C(N=C(NCCCN2C=NC=C2)N3CC4=CC=C(C=CC=C5)C5=C4)=C3C(NC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eg5-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eg5-IN-3KinesinMicrotubule/TubulinEg5Binding free energyMolecular dynamicsbipolar spindlesmitotic phaseInhibitorinhibitorinhibit

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