KIF11 Protein, Human

KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free. The total length of KIF11 Protein, Human is 368 a.a., .

The KIF11 protein plays a pivotal role in cellular processes, functioning as a motor protein crucial for the formation of a bipolar spindle during mitosis. Its significance extends beyond mitotic activities, as KIF11 is essential in non-mitotic cells, facilitating the transportation of secretory proteins from the Golgi complex to the cell surface. Notably, KIF11 engages in intricate interactions, including its binding to the thyroid hormone receptor in the presence of thyroid hormone. Moreover, KIF11 is a key component of a substantial chromatin remodeling complex, alongside MYSM1, PCAF, and RBM10, highlighting its involvement in chromatin dynamics. The protein further interacts, specifically via its C-terminus, with the kinase NEK6 during both interphase and mitosis, showcasing its versatile role. Additionally, KIF11 exhibits interactions with RARRES1 and AGBL2, emphasizing its diverse engagement in various cellular pathways.

Human

E. coli

Tag Free

P52732 (M1-K368)

3832

MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK

Approximately 41 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 5% glycerol, 1 mM DTT, 2 mM MgCl₂, pH 7.0.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.